摘要
慢性肾脏病发展至终末期可表现为肾小球硬化和(或)肾间质纤维化。有效抑制肾脏纤维化可显著延缓慢性肾脏病的进展。过氧化物酶体增殖物激活受体(PPARs)是配体激活的核转录因子超家族成员。PPAR-γ为PPARs的表型之一,在抑制肾脏纤维化方面的作用已成为当前研究的热点。文章就PPAR-γ及激动剂延缓肾脏纤维化研究新进展进行综述。
The end stage of chronic renal diseases is characterized by glomcrular sclerosis and interstitial fibrosis. Studies have revealed that effective amelioration of renal fibrosis can significantly delay the progression of chronic renal diseases. Peroxisome proliferator activated receptors （PPARs） are ligand-activated nuclear transcriptional factors of the nuclear hormone receptor superfamily, and PPAR-γ is one of the phenotypes of PPARs. The effect of PPAR-γ on inhibiting renal fibrosis has become a hot spot. In this article the research advances of PPAR-γ in amelioration of renal fibrosis are reviewed.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第1期104-107,共4页
Journal of Shanghai Jiao tong University:Medical Science
关键词
过氧化物酶体增殖物激活受体-Γ
慢性肾脏病
肾小球硬化
肾间质纤维化
peroxisome proliferator activated receptor-γ
chronic kidney disease
glomerular sclerosis
renal interstitial fibrosis
