摘要
目的 对比分析初诊不同亚型非霍奇金淋巴瘤（NHL）患者病灶的代谢活性,探讨其与免疫表型之间的相关性.方法 回顾性分析北京大学第一医院核医学科2010年7月至2012年3月行18氟-氟代脱氧葡萄糖（18F-FDG） PET/CT显像的NHL患者资料.测量反映肿瘤代谢活性的最大标准化摄取值（SUVmax）,分析惰性B细胞NHL、侵袭性B细胞NHL及T细胞NHL SUVmax平均值之间的差异及SUVmax与免疫表型之间的相关性.结果 本组患者中,NHL SUVmax 0.9～40.3不等,96.3％（79/82）的患者病灶均可见较明显的18F-FDG摄取.同一淋巴瘤亚型之间SUVmax也明显不同.惰性B细胞NHL、侵袭性B细胞NHL、T细胞NHL SUVmax分别为4.5±2.4、13.1士7.6、8.0士3.8.惰性B细胞NHL SUVmax低于侵袭性B细胞NHL、T细胞NHL（P=0.000、P=0.03）;侵袭性B细胞NHL SUVmax高于惰性B细胞NHL、T细胞NHL SUVmax（P=0.000、P=0.005）.B细胞NHLSUVmax与Ki-67阳性率呈正相关（r=0.493,P=0.001）,与CD138表达呈负相关（r=-0.654,P=0.008）.T细胞NHL SUVmax与Ki-67阳性率无相关（P =0.213）,与CD56表达呈负相关（r=-0.545,P=0.044）.结论 不同NHL亚型FDG摄取明显不同,多数亚型呈FDG高摄取.惰性B细胞NHL代谢活性明显低于侵袭性B细胞NHL、T细胞NHL,侵袭性B细胞NHL代谢活性高于惰性B细胞NHL、T细胞NHL.B细胞NHL SUVmax与Ki-67表达呈正相关,与CD138表达呈负相关;T细胞NHL SUVmax与Ki-67表达无相关性,与CD56表达呈负相关.
Objective To compare the metabolic activity by 18F-fluorodeoxyglucose （18F-FDG）uptake across the various histologic subtypes of non-Hodgkin lymphoma （NHL） and to investigate the relationship between metabolic activity and immunophenotype.Methods Positron emission tomography/computed tomography （PET/CT） studies of patients with newly diagnosed NHL from Jul 2010 to Mar 2012 were retrospectively reviewed,82 patients were enrolled in our study according to the inclusion and exclusion criteria.The maximum standardized uptake value （SUVmax） of each patient reflecting the metabolic activity was recorded.Mean SUVmax of aggressive B-cell NHL,indolent B-cell NHL and T-cell NHL were compared.Pearson and Spearman test were used to analyze the relationship between SUVmax and immunophenotype.Results The SUVmax of various subtypes of lymphoma revealed a wide range from 0.9 to 40.3,but lesions of 79 patients in this study showed obviously FDG uptake.SUVmax of indolent B-cell NHL （4.5 ±2.4） was significantly lower than that of aggressive B-cell NHL （13.1 ±7.6） （P =0.000）,T-cell NHL （8.0 ± 3.8） （P =0.03）.SUVmax of aggressive B-cell NHL was significantly higher than that of indolent B-cell NHL,T-cell NHL （P =0.000,P =0.005）.SUVmax of B-cell NHL had positive correlation with Ki-67 expression （r =0.493,P =0.001） and negative correlation with CD138 （r =-0.654,P =0.008）.While SUVmax of T-cell NHL had no correlation with Ki-67 expression （P =0.213）,but had negative correlation with CD56 （r =-0.545,P =0.044）.Conclusions Different subtype of NHL manifests markedly different intensity of FDG uptake,but most lesions of lymphoma are FDG avid.Metabolic activity is lower in indolent B-cell NHL than in aggressive B-cell NHL and T-cell lymphoma,which is concordant with its aggressiveness.SUVmax of B-cell NHL correlates with expression of Ki-67 and CD138.SUVmax of T-cell NHL is associated with the expression of CD56,no correlation is detected between SUV max of T-cell NHL and Ki-67 prolif
出处
《中华医学杂志》
CAS
CSCD
北大核心
2014年第33期2576-2579,共4页
National Medical Journal of China
基金
国家自然科学基金（81071183）
国家重大科学仪器设备开发专项（2011YQ03011409）
国家“十二五”支撑项目基金（2014BAA03B03）
2014年度北京大学第一医院归国基金
