摘要
目的观察和比较同步放化疗与单纯放疗治疗Ⅲ期非小细胞肺癌(NSCLC)的临床疗效和毒副反应。方法将我院已确诊的40例Ⅲ期NSCLC患者,随机分入对照组和观察组各20例。对照组患者给予三维适形常规分割放疗,观察组患者在放疗基础上予以顺铂联合多西他赛化疗1周期。治疗后比较两组患者1年、3年生存率,有效率及毒副反应发生率。结果同步放化疗组和常规化疗组有效率分别为75.0%和35%,患者1年、3年总生存率分别为50.0%、40.0%和40.0%、12.5%,差异具有统计学意义。两组Ш度以上急性毒副反应发生率分别为31.0%和29.6%,差别无统计学意义。结论对Ш期NSCLC患者选择同步放化疗方案与单纯放疗方案相比,可提高患者临床疗效和生存率且毒副反应可耐受。
Objective To observe and evaluate the cutative effect of radiotherapy concurrent with chemotherapy in the treatment of patients with non-small cell lung cancer at stage Ⅲ. Methods 40 patients with NSCLC at stage Ⅲ were randomly divided into two groups,20 cases in each group. The control group was given routine radiotherapy,and the observation group was additionally given chemotherapy of cisplatin and docetaxel for one course. The survival rate of 1-year and 3-year,the total response rate and the incidence of acute toxicity were compoared between the two groups. Results The total response rate was 75. 0% and 35. 0% respectitvely in the observation group and the control group. The survival rates of 1-year and 3-year were 50. 0% and 40. 0% respectitvely in the observation group,which were much higher than that in the control group（ 40. 0% and 12. 5%）. Conclusion Chemoradiotherapy concurrent with radiotherapy can greatly improve the clinical effect and survival rate with tolerated acute toxicity in the treatment of patients with non-small cell lung cancer at stage Ⅲ.
出处
《临床肺科杂志》
2014年第10期1877-1879,共3页
Journal of Clinical Pulmonary Medicine
关键词
Ⅲ期非小细胞肺癌
同步放化疗
放射治疗
non-small cell lung cancer at stage Ⅲ
concurrent chemoradiotherapy
radiotherapy
