摘要
目的:调查济南军区青岛第二疗养院2010-2012年的抗菌药物使用情况,监测临床主要分离菌的耐药率,为合理使用抗菌药物提供参考。方法:对本院的抗菌药物使用情况、病原学检查及药敏试验结果进行调查并做分析。结果:2010-2012年DDDs居前24位的抗菌药物包括10种头孢菌素类、4种含β-内酰胺酶抑制剂的复方制剂、3种大环内酯类、2种头霉素类、2种碳青霉烯类、1种喹诺酮类、1种单环β-内酰胺类和1种林可霉素类。左氧氟沙星和头孢克洛的DDDs最高。在临床分离菌中最常见的5种菌为大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌、肺炎克雷伯菌和鲍曼不动杆菌。除鲍曼不动杆菌以外的其他G-菌对碳青霉烯类敏感,G+菌仅对万古霉素和利奈唑胺敏感。结论:本院的细菌耐药率较高,监控和规范抗菌药物使用非常必要。
Objective： To investigate the utilization of antibacterials and moniter drug resistance of commonly isolated bac- teria in the Second Qingdao Sanitarium of Ji＇nan Military Region from 2010 to 2012, so as to provide reference for rational use of antibacterials. Methods： The utilization of antibacterial agents, the results of etiological tests and drug sensitivity tests were collected and analyzed. Results： From 2010 to 2012, DDDs of the top 24 antibacterials included 10 kinds of cephalosporins, 4 kinds of compound preparations containing 13-1actamase inhibitors, 3 kinds of macrolides, 2 kinds of cephamycins, 2 kinds of car bapenems, 1 kind of quinolone, 1 kind of monocyclic lactam and 1 kind o{ lincomycin,with the DDDs of [evofloxacin and cefacIor being the highest. Escherich ia coli , Staphylococcus aureus , Pseudomonas aeruginosa , K lebsiella pneumoniae and Acinetobacter baurnannii were the most commonly isolated bacteria. Gram-negative bacteria except A. baumannii were sensitive to carbapenems,while gram-positive bacteria were sensitive to vancomycin and linezolid. Conclusion： The bacterial drug resistance rate in the hospital is relatively high. Therefore,it is absolutely necessary to supervise and standardize the utilization of antibaeterials.
出处
《药学服务与研究》
CAS
CSCD
2014年第4期290-293,共4页
Pharmaceutical Care and Research
关键词
抗菌药物
药物利用评审
细菌耐药性
合理用药
antibacterials
drug utilization review
bacterial drug resistance
rational use of drugs
