摘要
目的考察当归提取物与不同吸收促进剂对芍药苷在大鼠十二指肠吸收过程的影响,筛选最佳吸收促进剂。方法利用大鼠在体单向肠灌流模型,采用HPLC法测定灌流液中芍药苷含量,分别考察吐温80、羟丙基-β-环糊精、癸酸钠、去氧胆酸钠和当归提取物对吸收的促进作用。结果羟丙基-β-环糊精和当归提取物能显著提高芍药苷的肠道吸收速率,其次是癸酸钠和吐温80,而去氧胆酸钠则没有作用。结论羟丙基-β-环糊精和当归提取物可作为芍药苷口服制剂的吸收促进剂使用,中药当归配伍芍药使用是合理、有效的。
Objective To investigate the effects of different intestinal enhancers on the intestinal absorption of paeoniflrin. Methods Tween80,HP-β-CD,sodium caprate,sodium deoxycholate and angelica extract were chosen as the enhancers. In situ single pass intestinal perfusion model was performed to study the absorption of paeoniflorin. The concentration of paeoniflorin was determined by HPLC. Results HP-β-CD and angelica extract can significantly improve the rate of intestinal absorption of paeoniflorin,followed by sodium caprate and Tween 80,and sodium deoxycholate had no effect. Conclusion HP-β-CD and angelica extract could be used as oral formulations paeoniflorin absorption enhancers. Angelica and peony pairs were reasonable and effective.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2014年第9期2136-2138,共3页
Lishizhen Medicine and Materia Medica Research
基金
广东省科技计划项目(No.2011B031700060)
