摘要
目的研究橙皮苷水溶液在不同的pH、温度、离子强度、初始浓度条件下降解反应的动力学特征。方法采用高效液相色谱法考察不同条件下橙皮苷含量随时间的变化,利用化学反应动力学的方法计算橙皮苷在不同环境下的降解反应动力学参数,预测其半衰期(t0.5)和活化能。结果橙皮苷在不同环境条件下的降解反应均遵循一级动力学规律,在酸性pH环境中最为稳定,碱性条件下较容易降解,pH=10时的半衰期为2.56 h,活化能为24.73 kJ·mol-1,离子强度和初始浓度对其降解影响不大。结论橙皮苷在酸性水溶液中较为稳定,随着pH的增大降解速率逐渐加快,呈现pH和温度依赖型,提示橙皮苷的使用和保存适宜在低温偏酸性条件下,避免碱性环境和高温条件。
Objective To investigate the degradation kinetic characteristics of hesperidin in aqueous under different pH and temperatures. Methods The concentration change of hesperidin in aqueous solution was determined by HPLC under different pH and temperatures. Base on the chemical reaction kinetic,the parameters of degradation kinetics were calculated under different conditions. The activation energy and half-life were evaluated. Results The results indicated that thermal degradation kinetic model of hesperidin in aqueous solution follows first-order degradation kinetic process. The half-life period（ t0. 5） was 2.56 hours under pH10 in aqueous solution,and the energy of activation（ Ea） was 24. 73 kJ·mol-1. Conclusion Hesperidin was more stable in acidic aqueous solution and low temperature condition. The degradation of hesperidin can be observed in strong alkali conditions.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2014年第9期2088-2090,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金青年基金项目(No.81202851)
高等学校博士学科点专项科研基金项目(新教师类)(No.20121210120003)
关键词
橙皮苷
水溶液
降解动力学
Hesperidin
Aqueous solution
Degradation kinetics
