摘要
目的 探讨转录因子Sp1在肾盂尿路上皮细胞癌（肾盂癌）的表达及其临床意义.方法 采用免疫组织化学PV-9000法检测Sp1蛋白在43例肾盂癌标本和11例肾盂正常黏膜组织的表达水平.结果 Sp1蛋白在肾盂癌和黏膜组织中的阳性表达率分别为74.4％（32/43）和0,组间差异有统计学意义（P＜0.05）.Sp1在低分级和高分级肾盂癌组织中的阳性表达率分别为59.1％（13/22）和90.5％（19/21）,Sp1在浅表性（Tis～T1）和浸润性（T2～T4）肾盂癌组织中的阳性表达率分别为58.3％（14/24）和94.7％（18/19）,组间差异有统计学意义（P＜0.05）.结论 转录因子Sp1蛋白在肾盂癌组织中呈高表达,且其阳性表达与肿瘤的组织学分级和T分期呈正相关,提示Sp1参与了肾盂癌的发生和进展过程.
Objective To investigate the expression and clinical significance of transcription factor Sp1 in uroepithelial cell carcinoma （UCC） of renal pelvis.Methods The immunohistochemical PV-9000 method was used to study the expression level of Sp1 protein in 43 cases of UCC and 11 cases of normal mucosa in renal pelvis.Results The positive expression rate of Sp1 protein in UCC and normal mucosa of renal pelvis was 74.4％ and 0 （P ＜ 0.05）,and that in low-grade and high-grade UCC of renal pelvis was 59.1％ and 90.5％ （P ＜ 0.05）,that in superficial and infiltrated UCC of renal pelvis was 58.3％ and 94.7％ （P ＜ 0.05）,respectively.Conclusion The positive expression of Sp1 protein is directly related to the histological grades and T stages of UCC in renal pelvis,suggesting Sp1 may participate in the carcinogenesis and progression of UCC.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第9期2053-2054,共2页
Chinese Journal of Experimental Surgery
关键词
肾盂
尿路上皮癌
转录因子SP1
Renal pelvis
Uroepithelial cell carcinoma
Transcription factor Spl
