摘要
炎症小体是一种存在于细胞浆中的多蛋白复合物,是机体固有免疫的重要组分之一。在核苷酸结合寡聚化结构域(NOD)样受体家族(NOD-like receptors,NLRs)中,NLRP3炎症小体主要是由NLRP3、凋亡相关的斑点样蛋白(ASC)和半胱氨酸的天冬氨酸蛋白水解酶(Caspase-1)等相互结合而形成的,具有调节免疫和抗微生物等作用。近年来发现其在多种肝脏疾病的发生、发展过程中发挥着巨大作用。本文主要介绍NLRP3炎症小体的激活通路、作用机制、表达调控及其与肝脏疾病发病的关系。
The inflammasome is a sort of multiprotein complexes in the cytoplasm,acting as an important component of the body＇s innate immune. The nucleotide-binding oligomerization domain（NOD）-like receptors（NLRs）,for example the NLRP3,mainly consists of NLRP3,apoptosis-associated speck-like protein（ASC）and cysteinyl aspartate specific proteinase（Caspase-1）,which plays a vital roles in the immune regulation and antimicrobial activities. In recent years,there has been a growing number of evidence indicating that NLRP3,the inflammasome,may be closely associated with all kinds of liver diseases. The activation pathway,regulatory mechanism of NLRP3 and its relationship with liver diseases were reviewed.
出处
《实用肝脏病杂志》
CAS
2014年第5期546-549,共4页
Journal of Practical Hepatology
基金
天津市科委基金项目(编号:13RCGFSY19200)
国家科技第十二五重大专项(编号:2012ZX10002004-011)
