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缬更昔洛韦与更昔洛韦在肾移植后预防和减少巨细胞病毒感染发生率的比较 被引量:3

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摘要 巨细胞病毒(CMV)在正常人体内处于潜伏状态,只有在机体免疫功能减弱时才会被激活[1]。肾移植受者术后应用免疫抑制药物,通常在移植后最初几个月内感染CMV,如不及时治疗,其病死率可高达90%[2]。目前治疗CMV感染最常用的药物为更昔洛韦和缬更昔洛韦。缬更昔洛韦是更昔洛韦的单缬氨酰酯,其生物利用度较更昔洛韦高约10倍,且口服吸收利用度与更昔洛韦相似。有研究表明使用缬更昔洛韦及更昔洛韦先行性预防治疗不仅可有效预防和治疗肾移植后CMV感染,并且可减少患者总体医疗费用。现报告如下。
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2014年第8期507-508,共2页 Chinese Journal of Organ Transplantation
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  • 1Prichard MN, Kern ER. The search for new therapies for human eytomegalovirus infections[J]. Virus Res, 2011, 157 (2) :212-221. 被引量:1
  • 2Paya C, Humar A, Dominguez E, et al. Fficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients [J]. Am J Transplant, 2004, 4(4) :611-620. 被引量:1
  • 3H6rl MP, Schmitz M, Ivens K, et al. Opportunistic infections after renal transplantation[J]. Curr Opin Urol, 2002, 12(2): 115-123. 被引量:1
  • 4Sarmiento JM, Dockrell DH, Schwab TR, et al. Mycophenolate mofetil increases cytomegalovirus invasive organ disease in renal transplant patients[J]. Clin Transplant, 2000, 14(2) : 136-138. 被引量:1
  • 5Winston D J, Busuttil RW. Randomized controlled trial of sequential intravenous and oral ganciclovir versus prolonged intravenous ganciclovir for long-term prophylaxis of cytomegalovirus disease in high-risk cytomegalovirus- seronegative liver transplant recipients with cytomegalovirus- seropositive donors[J]. Transplantation, 2004, 77 (2), 305- 308. 被引量:1
  • 6托娅,张春媛,薛爱军.227例肾移植患者巨细胞病毒抗体检测分析[J].中国疗养医学,2010,19(6):554-555. 被引量:4
  • 7Arichi N, Kishikawa H, Mitsui Y, et al. Cluster outbreak of Pneumocystis pneumonia among kidney transplant patients within a single center[J]. Transplant Proe, 2009, 41(1): 170- 172. 被引量:1
  • 8Neff RT, Jindal RM, Yoo DY, et al. Analysis of USRDS incidence and risk factors for Pneumocystis jiroveci pneumonia I-iT. Transplantation, 2009, 88(1):135-141. 被引量:1
  • 9YazakiH, Goto N, Uchida K, et a[. Outbreak of Pneumocystis jiroveci pneumonia in renal transplant reeipients P. jiroveci is contagious to the susceptible host [J]. Transplantation, 2009, 88(3):380-385. 被引量:1
  • 10RabodonirinaM, Vanhems P, Couray-Targe S, et al. Molecular evidence of interhuman transmission of Pneumocystis pneumonia among renal transplant recipients hospitalized with HIV-infected patients[J]. Emerg Infect Dis, 2004, 10(10) : 1766-1773. 被引量:1

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