摘要
目的:探讨胰岛素样生长因子结合蛋白5(insulin-iike growth factor binding protein5,IGFBP5)在胃腺癌中的表达及临床意义。方法:应用免疫组织化学检测236例胃腺癌手术切除术后标本中IGFBP5的表达,并探讨其表达与患者临床病理参数的相关性及对于胃腺癌的预后意义。结果:免疫组织化学结果显示,236例患者中159例(67.4%)IGFBP5表达下调,且在肿瘤大小>5 cm、低分化胃腺癌、T3+T4a/b及Ⅲ/Ⅳ期胃癌患者中表达下调明显(P<0.05)。生存分析显示IGFBP5低表达患者预后较差(P<0.05)。多因素分析显示IGFBP5可作为一个独立预后风险因素(HR=1.897,P=0.029)。结论:胃腺癌中IGFBP5的表达下调,与进展期的临床病理参数相关,且提示预后不良。
Objective： To investigate the expression and prognostic significance of insulin-like growth factor binding protein 5 （IGFBP5） in gastric adenocarcinoma （GAC）. Methods：IGFBP5 expression in tissue samples from 236 GAC patients was analyzed us-ing immunohistochemical methods. These patients had undergone surgical resection between 20003 and 2006 in Sun Yat-Sen Universi-ty Cancer Center. The relationship between IGFBP5 expression and clinicopathological factors in the 236 GAC patients was analyzed using Pearson correlation analysis. The significance of IGFBP5 in predicting the survival status of these patients was analyzed using Ka-plan-Meier survival analysis and Cox＆#39;s proportional hazards regression model. Results：Immunohistochemical staining data indicated that IGFBP5 expression was significantly decreased in 159 of the total GAC cases （67.4%）. Of the 62 cases with well-and moderately differentiated GAC, 31 （50%） exhibited reduced IGFBP5 expression. Of the 174 cases with poorly differentiated GAC, 128 showed re-duced IGFBP5 expression. Reduced IGFBP5 expression was also observed in female patients and in patients with tumors over 5 cm in size or with poorly differentiated tumors （P〈0.05）. The reduced expression of IGFBP5 was common in the tumors that were staged as T3＋4a/b andⅢ/Ⅳ（P〈0.05）. Kaplan-Meier survival analysis revealed that the reduced expression of IGFBP5 was associated with poor prognosis in GAC patients （P〈0.001）. Cox regression analysis identified IGFBP5 expression as an independent prognostic factor for the overall survival of these cancer patients （HR=1.897, P=0.029）. Conclusion： IGFBP5 expression is reduced in GAC tissues, and IGFBP5 independently predicts an unfavorable prognosis in GAC patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2014年第16期1031-1035,共5页
Chinese Journal of Clinical Oncology
基金
贵州省科技厅资助项目(编号:黔科合J字[2013]2312号)资助
关键词
IGFBP5
胃腺癌
多因素分析
预后
IGFBP5 gastric adenocarcinoma
multivariate analysis
prognosis
