摘要
目的评价复方甘草酸苷注射液预防带状疱疹后遗神经痛（postherpesneuralgia，PHN）的临床疗效。方法将入选的60例患者随机分为两组，试验组予以复方甘草酸苷和阿昔洛韦联合治疗，对照组予以阿昔洛韦治疗，记录止疱时间、疼痛减轻时间和疼痛消失时间，治疗结束时评价疗效，治疗结束1个月后随访PHN的发生情况。结果试验组止疱时间[（4．10±1．65）天]、疼痛减轻时间[（3．27±2．02）天]、疼痛消失时间[（17．20±11．52）天]均短于对照组[（5．70±1．86）天、（6．73±2．59）天、（51．83±37．72）天1，两组比较差异均有统计学意义（P〈0．05）；PHN的发生率试验组（10．00％）低于对照组（53．33％），两组比较差异有统计学意义（P〈0．05）。结论复方甘草酸苷注射液预防PHN安全、有效。
Objective To evaluate the clinical therapy efficacy of compound glyeyrrhizin in prevention of senile postherpetic neuralgia （PHN）. Methods 60 cases with herpes zoster were randomly divided into two groups. The patients in test group were treated with a combination of compound glycynthizin and acyelovir, the control group was treated with acyclovir alone. The time of blister recession, the time ofpain alleviation and the time of pain disappearance were observed and recorded respectively. The incidence of PHN was observed a month after treatment. Resttlts There was significant difference between two groups on the time of blister recession, the time of pain alleviation and the time of pain disappearance （all P 〈 0.05）. There was significant difference between two groups on the incidence of PHN （P 〈 0.05）. Conclusion The therapy of compound glyeyrrhizin in prevention of senile postherpetic neuralgia is effective and safe.
出处
《国际医药卫生导报》
2014年第17期2704-2707,共4页
International Medicine and Health Guidance News
关键词
带状疱疹
神经痛
复方甘草酸苷
Herpes zoster
Neuralgia
Compound glyeyrrhizin
