摘要
目的 探讨妇科病原菌分布及抗菌药物的使用情况,为临床合理用药提供依据。方法 回顾性分析2010年1月至2012年12月医院妇科234例住院感染患者的临床资料,观察感染率、病原菌分布及耐药性。结果 随着时间增长,医院感染发生率不断上升;50~59岁和开腹手术的患者感染率最高;病原菌以革兰阴性菌为主（137株,58.55%）,革兰阳性菌65株（27.78%）,真菌32株（13.68%）;革兰阴性杆菌对阿米卡星、亚胺培南敏感率较高,革兰阳性杆菌对左氧氟沙星、头孢哌酮舒巴坦敏感率较高;一、二、三联抗菌药物使用率分别为24.36%,70.94%,4.70%,无超三联用药。结论 根据妇科住院感染患者病原菌分布特点和耐药性合理使用抗菌药物,能有效控制医院感染率。
Objective To investigate the distribution of pathogens and antibiotics use in the gynecology department in order to provide the basis for clinical rational drug use. Methods The data of 234 inpatients with infection in our hospital from January 2010 to December 2012 were retrospectively analyzed for observing the infection rate,pathogen distribution and drug resistance. Results With the passage of time,the positive detection rate was constantly ascended;the infection rate in the inpatients aged 50-59 years old and with open operation was highest;pathogens were dominated by Grain negative bacteria, 137 strains,accounting for 58.55% ;65 strains were Gram positive bacteria,accounting for 27.78% ;32 strains were fungi,accounting for 13.68% ;Gram negative bacilli had the higher sen- sitive rate to amikacin and imipenem,Gram positive bacilli had the higher sensitive rate to levofloxacin and cefoperazone/sulbactam;the use rates of single drug, two-drug and three-drug combination were 24. 36% ,70.94% and 4.70% respectively,without more than threedrug combination. Conclusion According to the pathogenic bacteria distribution characteristics and drug resistance in the gynecological infection inpatients,the rational use of antibiotics can effectively control the hospital infection rate.
出处
《中国药业》
CAS
2014年第16期78-79,共2页
China Pharmaceuticals
关键词
病原菌
耐药性
感染率
合理用药
pathogenic bacteria
drug resistance
infection rate
rational drug use
