摘要
间质性肺疾病(ILD)种类繁多、诊断困难。ILD的生物学标志物可用于该类疾病的诊断、鉴别诊断、预后判断和监测病情变化等。文章介绍了KL-6、表面活性蛋白A(SP-A)、基质金属蛋白酶(MMP7)、循环纤维细胞等10余种生物学标志物,截至目前具有多种功能的单一生物学标志物的筛选基本不可能,可联合几种生物学标志物来达到临床诊断的目的。
There are many different kinds of disease spectrums in interstitial lung diseases （ILD） whose diagnosis was diffi- cult. Biological markers of ILD can be used for the diagnosis, differential diagnosis, prognosis judgment and disease condition monitoring. More than 10 kinds of biological markers are introduced in this paper,including KL-6, SP-A, MMP7 and circu- lating fibrocytes,etc. Up to now,it is unlikely that a single biomarker is able to be used as valuable diagnostic tool. A com- posite of several biomarkers may hold promise.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2014年第8期748-751,共4页
Chinese Journal of Practical Internal Medicine
基金
天津市应用技术研究与前沿技术研究计划项目(11JCYBJC1180)
武警医学院博士启动基金(WBS200808)
关键词
间质性肺疾病
生物学标志物
interstitial lung diseases
biological markers
