摘要
支气管哮喘（简称哮喘）气道重塑是慢性哮喘不可逆性气流受限的重要原因，是由多种细胞共同作用最终导致气道结构异常的过程，目前机制尚未完全明确。近年来，越来越多的研究结果表明，循环纤维细胞在哮喘的气道重塑中发挥着重要作用。本文就循环纤维细胞的基本生物学特性以及其参与哮喘气道重塑的研究现状及进展作一综述。
The structural remodeling of airway is an important cause of the development of progressive airflow obstruction in chronic asthma. This process is resulted from the effect of a variety of cells and leads to the abnormal structure of airways. However, the mechanism is not completely clear. In recent studies,there is increased evidence suggesting that the circulating fibrocytes play an important role in airway remodeling of asthma. This review aims to summarize the basic biological characteristics of fibrocytes and the current understanding and evidences of fibrocytes in the pathogenesis of airway remodeling in chronic asthma.
出处
《国际呼吸杂志》
2014年第5期367-371,共5页
International Journal of Respiration
基金
国家自然科学基金（81270069）
