摘要
目的探讨脂质饮食对Beagle犬体内左氧氟沙星(Lfox)药动学的影响。方法 6只Beagle犬分别在空腹或进食脂质状态下灌服Lfox胶囊10mg/kg,2周后交叉给药;采用高效液相色谱法测定不同时间(48h内)血药浓度,用3p97软件计算二者的药动学参数并进行比较。结果 Beagle犬空腹组和进食脂质组的药-时曲线均符合二室模型;空腹组和进食脂质组Lfox主要药动学参数t1/2β分别为(11.07±8.46)、(21.79±4.59)h,tmax分别为(3.42±0.41)、(2.00±0.32)h,Cmax分别为(2.71±0.60)、(2.52±0.38)μg/mL,AUC0→t分别为(36.51±8.66)、(37.19±8.21)μg·h-1·mL-1;除Ka、t1/2Ka、CL(F)、tmax参数两组比较差异均有统计学意义(P<0.01或<0.05)外,其他参数比较差异均无统计学意义(P>0.05)。结论脂质饮食可使Beagle犬体内Lfox的吸收加快,tmax提前到达,而t1/2β/h延长,排出减慢,有益于Lfox在体内的储留。
Objective To study the effect of lipide diet on pharmacokinetics of levofloxacin （Lfox） in beagle dogs .Methods In randomized cross over experiment ,6 Beagle dogs were given Lfox 10 mg/kg at the condition of empty stomach or with lipide diet for 2 week .Plasma concentration of Lfox was determined by HPLC at different time （during 48 h） .The pharmacokinetic parameters were calculated by 3p97 software .Results The plasma concentration-time curves were two compartment modelat the condition of empty stomach or lipide diet .Main pharmacokinetic parameters were as follows ：t1/2β：（11 .07 ± 8 .46）and（21 .79 ± 4 .59）h ;tmax ：（3 .42 ± 0 .41） and（2 .00 ± 0 .32）h;Cmax ：（2 .71 ± 0 .60）and（2 .52 ± 0 .38）μg/mL ;AUC0→ t ：（36 .51 ± 8 .66） and（37 .19 ± 8 .21）μg · h-1 · mL -1 ,respectively .There were significant differences in pharmacokinetic parameters of tmax （P〈0 .01）except for t1/2β、Cmax and AUC0→ t .Conclusion Lipide diet can quicken tmax ,has no effect on the absorption of Lfox .
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第24期3184-3186,共3页
Chongqing medicine
