摘要
本文报道８例健康志愿者体内单次及多次给予３００ｍｇＬｅｖｏｆｌｏｘａｃｉｎ后的药代动力学研究。血药浓度及尿药浓度采用微生物和ＨＰＬＣ测定。单次及多次给药后的数据分别采用３ｐ８７及ＳＳＤ程序处理，药－时曲线符合二室模型。单次口服３００ｍｇＬｅｖｏｆｌｏｘａｃｉｎ，其微生物和ＨＰＬＣ测定结果分别为Ｔｍａｘ１．３１和１．４３ｈ，Ｃｍａｘ３．８４和４．２０ｍｇ／Ｌ，ｔ１／２２６．１２和６．０６ｈ。０～２４ｈ尿药回收率分别为６８．７９和６６．４３％。经ｔ检验两种方法的测定结果无显著性差异（ｐ＞０．０５）。在每日３００ｍｇｑ１２ｈ连续８天的多次口服给药实验中，第１天和第８天的药代动力学参数经ｔ－检验无显著性差异（ｐ＞０．０５），说明本品每日２次重复给药无明显蓄积现象。
Pharmacokinetic of Levofloxacin was studied in 8 healthy volunteers after a single-dose or multiple-dose of 300mg.The Levofloxacin concentrations in serum and in urine were measured by both H PLC and bioassay,The pharmacokinetic parameters were obtained by using 3p87 or SSD program and calculated on the basis of two compartment model.In single-dose study,each of eight volunteers was given a single dose of 300mg of Levofloxacin orally,The pharmacokinetic parameters obtained from bioassay and HPLC were:T_(max):1.31 and 1.43h;C_(max):3.84 and 4.20mg/L;t1/2:6.12 and 6.06h and the urinary recovery rates(0～24) 68.79%and 66.43%respectively.The pharmacokinetic parameters obtained from single-dose study showed no singnificant difference between two methods of ass ay(p>0.05).During multiple dose study,300mg of Levofloxacin was administrated orally q12h each day for 8 consecutive days.The pharmacokinetic parameters on day 1 and day 8 showed no significent diffences(p>0.05).No obvious accumlation of the drug was noted in multiple-dose administration.
出处
《中国药房》
CAS
CSCD
1995年第6期23-24,共2页
China Pharmacy
