摘要
长非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200个核苷酸但缺乏蛋白质编码潜力的调控型RNA。lncRNA在真核生物基因组中广泛转录,并且能够在多种层次以灵活的方式对基因表达进行调控。lncRNA能够与染色质修饰复合物及转录因子等蛋白质相互作用,这种相互作用提高了基因表达调控的灵活性和复杂性。本文将介绍部分具有代表性的lncRNA-蛋白质相互作用及其在基因表达调控中的作用。
Long non-coding RNAs （lncRNAs） are transcripts larger than 200 nt in length with limited pro-tein-coding potential. Eukaryotic genomes are pervasively transcribed into tens of thousands of lncRNAs.LncRNAs play widespread roles in gene regulation by diverse mechanisms. LncRNAs interact with proteinpartners such as chromatin-modification proteins and transcription factors. These lncRNA-protein interactionsincreased the flexibility and complexity of gene regulation. Here we review representative lncRNA-proteininteractions and their roles in the regulation ofgene expression.
出处
《生命的化学》
CAS
CSCD
2014年第4期473-478,共6页
Chemistry of Life
基金
教育部博士点基金优先发展领域(20130181130010)
