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活细胞内RNA标记和成像技术

The technologies of RNA labeling and imaging in living cells
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摘要 RNA根据其定位、结构、修饰以及与其他生物分子的动态相互作用,复杂而精确地执行丰富多彩的功能。RNA-蛋白质相互作用和RNA在细胞内定位的异常与多种疾病的发生发展密切相关。活细胞RNA标记和成像技术已成为研究RNA定位和运动、基因转录调控及RNA-蛋白质相互作用等生物学过程的有力工具。活细胞RNA标记和成像技术的开发已成为国际科学研究领域的热点。将目前存在的活细胞内RNA标记和成像技术方面的研究进展进行概述。 RNA performs a variety of important biological functions. The disorder of RNA-protein interactions and RNA localization is closely related to the occurrence of disease. The technologies of RNA labeling and imaging in living cells have been useful tools for studying RNA location and movement, gene transcription regulation and RNA-protein interactions. The exploitation of the technologies for RNA labeling and imaging has also attracted the attention of many scientists.
出处 《生命科学》 CSCD 2014年第3期214-218,共5页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(31000364)
关键词 活细胞 RNA 成像 living cells RNA imaging
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参考文献25

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