摘要
目的探讨产妇分娩前后凝血与纤溶指标监测的意义。方法产后出血组(出血量大于或等于500mL)212例和正常分娩组235例,检测产前及产后72h血浆凝血酶原时间(PT)、国际标准化比值(PT-INR)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、D-二聚体(DD)、血小板(PLT)和血红蛋白(HB),健康体检女性85例作为健康组。结果产前比较:正常分娩组PT/PT-INR、APTT、TT、PLT、HB低于健康组,FIB、DD高于健康组;产后出血组PT/PT-INR、APTT、TT、DD高于正常分娩组,FIB、PLT低于正常分娩组。产后比较:正常分娩组PT/PT-INR、APTT、TT、DD与健康组比较差异无统计学意义(P>0.05),但FIB高于健康组;产后出血组PT/PT-INR、APTT、TT、DD高于正常分娩组,FIB、PLT、HB低于正常分娩组。结论产前及产后动态监测各项凝血与纤溶指标变化对预防产后出血、血栓形成具有重要意义。
Objective To investigate the significance of detection of blood coagulation and fibrinolytic indexes before and after delivery.Methods 212 cases in the postpartum hemorrhage group（bleeding amount ≥500 mL）and 235 cases in the normal deliver-y group were retrospectively analyzed.The prothrombin time（PT）,international normalized ratio（PT-INR）,activated partial throm-boplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB）,D-dimer（DD）,blood platelets（PLT）and hemoglobin（HB）were de-tected before delivery and at 72 h after delivery.85 women with the physical examination were selected as the healthy group.Results Before delivery,PT/PT-INR,APTT,TT,PLT and HB in the normal delivery group were lower than those in the healthy group, while FIB and DD were higher than those in the healthy group;PT/PT-INR,APTT,TT and DD in the postpartum hemorrhage group were higher than those in the normal delivery group,while FIB and PLT were lower than those in the normal delivery group. At 72 h after delivery,there was no statistically significant differences in PT/PT-INR,APTT,TT and DD between the normal de-livery group and the healthy group（P ＆gt;0.05）,but FIB was higher than that in the healthy group;PT/PT-INR,APTT,TT and DD in the postpartum hemorrhage group were higher than those in the normal delivery group,while FIB,PLT and HB were lower than those in the normal delivery group.Conclusion Dynamically monitoring the change of the blood coagulation and fibrinolysis indexes before and after delivery has important significance in preventing postpartum hemorrhage and thrombosis.
出处
《国际检验医学杂志》
CAS
2014年第16期2179-2180,共2页
International Journal of Laboratory Medicine
关键词
产后出血
凝血
纤溶
postpartum hemorrhage
coagulation
fibrinolysis
