摘要
目的:对通心络胶囊治疗急性脑梗死的临床效果进行评价,为临床应用提供循证医学证据。方法:全面检索通心络胶囊治疗急性脑梗死的临床研究文献,并按照文献选择标准进行筛选,对符合纳入标准的文献进行质量评价。采用RevMan5.0软件对以基础治疗为对照组,在基础治疗上加用通心络胶囊治疗作为治疗组的随机对照试验进行Meta分析。结果:共纳入13篇文献,通心络组治疗急性脑梗死的疗效高于对照组,无明显不良反应。合并RR=1.26,95%CI[1.20,1.33]。结论:通心络治疗急性脑梗死的疗效优于对照组,但由于本研究存在一定的不足,对其疗效及安全性仍有待大样本、多中心、随机对照试验加以验证。
Objective： To assess the effectiveness of Tongxinluo capsules in the treatment of acute cerebral infarction by Meta-analysis. Methods：The clinical studies of Tongxinluo capsules in treating acute cerebral infarction were collected and selected according to the criteria. Randomized controlled trials with the control group using basic treatment, while the treatment group using basic treatment combined with Tongxinluo capsules were included in this Meta-analysis. Results： A total of 13 RCTs were included. Tongxinluo treatment group showed better effectiveness than the control group. Adverse drug reactions and other harmful consequences weren＆#39;t reported. The combined risk ratio （RR） was 1.26, 95%CI was [1.20, 1.33]. Conclusion：Our results showed Tongxinluo group was superior to control group in treating acute cerebral infarction. However, existence of some data methodological defects maybe directly affect the authenticity of the results. High quality, large samples and multiple center randomized controlled trials were needed to conifrm the efifcacy and safety.
出处
《中国药物应用与监测》
CAS
2014年第4期201-203,223,共4页
Chinese Journal of Drug Application and Monitoring
关键词
急性脑梗死
通心络胶囊
META分析
Acute cerebral infarction
Tongxinluo capsules
Meta-analysis
