摘要
选取9例左侧乳腺癌根治术后患者和13例食管癌患者,所有PTV均包括锁骨上区域,分别采用不同的照射野等中心(PTV中心和卷入PTV内的肺体积情况确定的中心)制定不同的调强计划(IMRT-PTV和IMRT-肺),根据剂量体积直方图(DVH)分析两种计划中的PTV和正常组织在剂量学上的差异。结果显示,IMRT-肺计划能显著降低左侧乳腺癌根治术后患者的左肺V20和心脏V30剂量(t=-6.154、-5.084,p=0.038、0.040),能显著减少食管癌的左肺V20、V30、右肺V30和心脏V40值(t=-7.493、-8.092、-6.332、-6.945,p=0.025、0.019、0.042、0.032),但并不能降低其他正常组织的剂量。结果表明根据卷入PTV内的肺体积情况调整照射野等中心位置能降低靶区周边的部分正常组织剂量。
Nine patients suffering with left breast cancer after radical mastectomy and thirteen patients suffering with esophagus cancer were selected. All plan target volumes （PTV） included supraclavicular areas. Two IMRT plans（IMRT-PTV and IMRT-lung） for 22 patients were developed according to different isocenter positions （PTV center and the center determined by the lung volume in PTV）. The dosimetric differences of PTV and normal tissues were analyzed using dose-volume histogram （DVH） for the two IMRT plans. The results showed that left lung/I20 and heart 1130 of the left breast cancer after radical mastectomy IMRT-lung plans dropped significantly（t=-6.154, -5.084; p=0.038, 0.040）, and left lung V20, V30, right lung V30 and heart V40 of the Esophagus cancer IMRT-Lung plans were also significantly lower（t-=-7.493, -8.092, -6.332, -6.945; p=0.025, 0.019, 0.042, 0.032）, but not for other normal tissues. These findings indicate that changing isocenter position based on the lung volume involved in PTV can obtain the fewer dose of some normal tissues around the target volume.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2014年第4期21-26,共6页
Journal of Radiation Research and Radiation Processing
关键词
等中心位置
大体积肿瘤
调强
剂量学
Isocenter position, Large target volume, Intensity modulated radiationtherapy, Dosimetry
