摘要
目的综述近年来天然药物经皮给药制剂在新剂型、新技术方面研究的最新进展。方法查阅近年来发表的有关天然药物经皮给药系统的研究论文,从新剂型、新技术两方面进行梳理分析。结果经皮给药系统具有控释、易去除、局部浓度高、安全性强、副作用小等特点,已经成为药品市场上重要的一种剂型。天然药物经皮给药新剂型包括纳米粒、微乳、囊泡、前药和液晶;新技术包括透皮渗透促进剂、离子导入、超声促渗。结论综合运用上述新剂型和新技术,达到增加天然药物有效成分经皮吸收和控释的目的,提升我国天然药物经皮给药系统的研发水平。
OBJECTIVE To summarize the latest research progress in formulations and technologies of transdermal drug delivery system （TDDS） for natural drugs. METHODS The research articles published in the past six years related to TDDS for natural drugs were reviewed from the perspectives of formulations and technologies. RESULTS Transdermal drug delivery systems have the advan- tages of controlled release, readily wiping off, high accumulation in situ, high safety and low side effect, which become an important dosage form in the pharmaceutical market. The novel dosage forms of TDDS for natural drugs include nanoparticles, microemulsions, vesicles, prodrugs and liquid crystalline. The related novel techniques include transdermal penetration enhancers, iontophoresis, and sonophoresis. CONCLUSION The trend of TDDS for natural drugs is to combine the novel forms and the techniques to improve drug transdermal absorption and controlled release. This may be advantageous for improving R＆D of TDDS for natural drugs.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2014年第16期1377-1381,共5页
Chinese Pharmaceutical Journal
关键词
天然药物
经皮给药系统
纳米粒
微乳
脂质体
natural drug
transdermal drug system
nanoparticle
mieroemulsion
liposome
