摘要
目的探讨婴儿骶尾部恶性肿瘤的临床病理特点、治疗及预后。方法对5例婴儿骶尾部恶性肿瘤进行常规镜检和免疫组化染色,并结合相关文献对其临床特点及病理特征进行分析。结果 5例婴儿骶尾部恶性肿瘤中4例女婴,1例男婴;患儿发病年龄从出生至4个月不等。肿瘤均原发于骶尾部,包括腺泡状横纹肌肉瘤1例。胚胎性癌1例,未成熟性畸胎瘤2例,卵黄囊瘤1例,除4例恶性生殖细胞肿瘤有AFP的显著增高外,其他临床症状不明显。结论骶尾部恶性肿瘤相对少见,多发生在新生儿、婴儿期,缺乏特异的临床表现,治疗上以手术治疗为主,并辅以放、化疗,但预后较差。
Objective To investigate the clincical pathologic feature,treatment and prognosis of sacrococcygeal malignant tumor of the infants.Method We collected 5 cases of hospitatized infants with sacrococcygeal malignant tumor in our hospital since 2006,and then conducted conventional microscopic examination and immunhistochemical staining,with review of the related literature to analyze the clinical and pathological features.Results In the 5 cases of infant sacrococcygeal malignant tumor,4 cases were female,and 1 case was male; onset age ranged from birth to 4 months.The tumors were primarily present in the sacrococcygeal region,including alveolar rhabdomyosarcoma in 1 cases,1 cases of embryonal carcinoma,2 cases of immature teratoma,and 1 cases of yolk sac tumor; except 4 cases of malignant germ cell tumors with significantly increased AFP level,other clinical symptoms were not obvious.Conclusion Sacrococcygeal malignant tumor is relatively rare,it typically occurs in the newborn infants,lack of specific clinical manifestations.Main treatment is surgery,supplemented with radiotherapy and chemotherapy,but prognosis is poor.
出处
《诊断病理学杂志》
CSCD
北大核心
2014年第7期431-434,共4页
Chinese Journal of Diagnostic Pathology
关键词
骶尾部
恶性肿瘤
病理学
免疫组化
Sacrococcygeal
Malignant tumor
Pathologic
Immunhistochemistry
