摘要
目的评价AVAP方案治疗儿童恶性生殖细胞肿瘤的临床疗效。方法选择2005年8月—2010年2月住院治疗的恶性生殖细胞肿瘤患儿25例,所有病例诊断均经手术病理活检证实,术后予AVAP方案按不同分期化疗6～12个月。分别计算Ⅰ、Ⅱ期及Ⅲ、Ⅳ期患儿生存率,及不同原发部位的生存率。结果Ⅰ、Ⅱ期生存率100%,Ⅲ期、Ⅳ期生存率55.6%,Ⅲ、Ⅳ期生存率明显低于Ⅰ、Ⅱ期(P=0.016)。性腺肿瘤生存率85.7%,性腺外肿瘤生存率66.7%,骶尾部肿瘤生存率60%。结论Ⅰ、Ⅱ期恶性生殖细胞肿瘤经手术及术后AVAP方案化疗,可获得理想的生存率;Ⅲ、Ⅳ期疗效不理想,需探寻更合适的治疗手段。性腺恶性生殖细胞肿瘤预后好于性腺外恶性生殖细胞肿瘤,骶尾部恶性生殖细胞肿瘤预后尤其不佳。
Objective To evaluate the clinical effect of AVAP therapy on treatment of childhood malignant germ cell tumor.Methods Clinical data of twenty-five patients with malignant germ cell tumors admitted form August 2005 to February 2010 were analyzed.All patients were confirmed by surgical biopsy and treated with AVAP chemotherapy for 6 to 12 months according to the different phases of the disease after surgery.Survival rates at different stages（Ⅰ,Ⅱ,Ⅲ,and Ⅳ）and different primary sites were calculated.Results The survival rate of patients in stage Ⅰor Ⅱ was 100%,while it was only 55.6% for the patients in stage Ⅲ or Ⅳ.The difference in survival rate between the two groups was significant（P = 0.016）.The survival rates for patients with gonadal tumor,extragonadal tumors,and sacrococcygeal tumor were 88.9%,71.4%,and 66.7%,respectively.Conclusions Patients with malignant germ cell tumors（stage Ⅰor Ⅱ）had an ideal survival rate after combining surgery and postoperative AVAP chemotherapy,while the effect was not satisfactory for patients with stage Ⅲ or Ⅳ.So more appropriate treatment needs to be explored.The prognosis of patients with gonadal malignant germ cell tumor was better than those with extragonadal malignant germ cell tumors,and prognosis of patients with sacrococcygeal malignant germ cell tumors was particularly poor.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2010年第12期1149-1151,共3页
Journal of Clinical Pediatrics
关键词
恶性生殖细胞肿瘤
化疗
儿童
malignant germ cell tumor
chemotherapy
children
