摘要
腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是细胞的能量调节器,在维持机体能量代谢平衡中发挥重要作用。最近研究表明,AMPK能通过调节氧化应激、抗炎等途径减轻哮喘、慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)、肺部感染性疾病、肺纤维化的肺组织损伤。AMPK主要通过下游靶分子如沉默信息调节因子1(sirtuin1,SIRT1)、过氧化物酶体增殖物激活受体γ共激活因子-1α(peroxisome proliferator-activated receptorγcoactivator-1α,PGC-1α)、p53和FoxO转录因子3a(forkhead box O3a,FoxO3a)等抑制肺部炎症反应。因此,AMPK及其信号通路有望成为治疗肺部炎症疾病的药理学靶点。本文就AMPK与肺部炎症疾病的关系进行综述。
AMP-activated protein kinase （AMPK） is an important regulator of cellular energy homeostasis. Recent studies demonstrated that AMPK is a novel signaling molecule modulating inflammatory responses and oxidative stress which are involved in inflammatory pulmonary diseases, such as asthma, chronic obstructive pulmonary disease （COPD）, pulmonary infectious diseases and pulmonary fibrosis. AMPK attenuates inflammatory lung injury by phosphorylating its downstream targets, such as sirtuinl （SIRT1）, peroxisome proliferatoractivated receptor γ coactivator-1α （PGC-1α）, p53 and forkhead box O3a （FoxO3a）. This review summarized the relationship between AMPK and the development of inflammatory pulmonary diseases.
出处
《药学学报》
CAS
CSCD
北大核心
2014年第8期1089-1096,共8页
Acta Pharmaceutica Sinica
基金
十二五综合大平台-药效学评价(37008)
医科院留学回国择优项目经费-哮喘炎症
