摘要
成纤维细胞受到各种刺激后可发生活化。并进而转化为表达α平滑肌肌动蛋白的肌成纤维细胞。转化生长因子β可抑制成纤维细胞调亡，而羟甲基戊二酸单酰辅酶A还原酶抑制剂等可促进成纤维细胞的凋亡。肌成纤维细胞能诱导肺泡上皮细胞的凋亡，促进肺纤维化的发生。
Fibroblasts can be activated by various stimulation and transformed to myofibroblasts expressed a-smooth muscle actin. Transforming growth factor β can inhibit myofibroblast apoptosis, but hydroxy-3-methylglutaryl-coenzyme A can promote myofibroblast apoptosis. Myofibroblasts can induce the apoptosis of alveolar epithelial cells and promote the development of pulmonary fibrosis.
出处
《国际呼吸杂志》
2007年第4期298-301,共4页
International Journal of Respiration
关键词
肺纤维化
肌成纤维细胞
肺泡上皮细胞
凋亡
Pulmonary fibrosis
Myofibroblasts
Alveolar epithelial cells
Apoptosis
