摘要
诺如病毒(norovirus, Nov)属于人类杯状病毒科,是引起病毒性腹泻的主要病原之一。诺如病毒非结构蛋白P48可能与高尔基体有相互作用,破坏蛋白质的运输。而非结构蛋白P22能抑制细胞的蛋白分泌。这些研究对了解诺如病毒复制和致病机理奠定基础,同时也为抗病毒的药物开发提供方向。
Norovirus ( Nov) belongs to the family of human Caliciviridae.It is a major causative agent of viral gastroenteritis.The non-structural protein P48 of Nov may interact with the Golgi apparatus, resulting in the destruction of protein transport.The non-structural protein P22 of Nov can inhibit the secretion of cell proteins.The studies on the non-structural proteins P48 and P22 not only lay a foundation for understanding the replication of norovirus and its pathogenesis , but also provide a new direction of developing the antiviral drugs.
出处
《医学分子生物学杂志》
CAS
2014年第4期223-227,共5页
Journal of Medical Molecular Biology
基金
国家自然科学基金(No.30872398)