摘要
目的探讨胃癌术后胰瘘的诊疗情况和相关危险因素。方法选取2006年12月至2012年12月间收治的417例胃癌根治术患者,回顾性分析胰瘘的诊疗情况和危险因素。结果 26例患者经确诊胰瘘后采用禁食、抑制胰腺分泌、抗感染、纠正酸碱平衡紊乱等治疗,25例患者在5-36 d后病情得以缓解。单因素分析结果显示,胰瘘组患者与非胰瘘组患者在年龄、术中出血量、肿瘤分期为Ⅲ-Ⅳ期和累及胰腺方面差异均有统计学意义（均P〈0.05）。多因素分析结果显示,年龄、累及胰腺、肿瘤分期为Ⅲ~Ⅳ期均为胰瘘发生的独立危险因素（均P〈0.05）。结论早期发现,采用禁食、抑制胰腺分泌、抗感染和纠正酸碱平衡紊乱治疗胰瘘患者可明显改善患者的预后。年龄较大、手术累及胰腺、肿瘤分期较晚的患者更易发生胰瘘。
Objective To observe the diagnosis and risk factors of pancreatic leakage after surgery of gastric carcinoma. Methods A total of 417 patients with advanced stomach neoplasms were collected from December 2006 to December 2012. The diagnosis and risk factors were retrospectively analyzed in patients with pancreatic leakage after surgery. Results 25 of 26 patients gained alleviation after combination therapy for 5 - 36 days. The results of univariate analysis showed that there was a significant differences （ P 〈 0. 05 ） in age, blood loss, phase Ⅲ - IV and involving pancreas between the two group （ pancreatic leakage and nonpancreatic leakage）. The results of multivariate analysis showed that age, involving pancreas and phase Ⅲ - IV were independent risk factors. Conclusions Early discovery and combination therapy would benefit for prognosis in patients with pancreatic leakage. Patients with older, involving pancreas and later stages were susceptible to pancreatic leakage.
出处
《中国肿瘤临床与康复》
2014年第8期902-904,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃肿瘤
胰瘘
诊疗
危险因素
Stomach neoplasms
Pancreatic leakage
Diagnosis
Risk factors
