摘要
目的观察3%氯化钠联合布地奈德及特布他林雾化吸入治疗婴幼儿先天性心脏病(CHD)外循环术后气道痉挛的疗效及安全性。方法选择2011年6月-2013年1月医院收治的先天性心脏病体外循环术后撤除呼吸机后发生气道痉挛喘息的患儿47例。随机分为对照组22例与观察组25例,对照组予雾化吸入地奈德及特布他林;观察组雾化吸入布地奈德、特布他林后雾化吸入3%氯化钠,观察比较2组症状缓解时间,雾化吸入前后呼吸、心率、血气分析PCO2、PO2、CICU滞留时间、再插管接呼吸机或无创CPAP患儿例数等进行分析。结果观察组气促缓解、喘鸣音消失、湿啰音消失的时间、CICU滞留时间、再插管接呼吸机或无创CPAP患儿例数明显小于对照组,2组比较差异有统计学意义(P<0.05),雾化吸入后PCO2<50mm Hg患儿例数小于对照组,2组比较差异有统计学意义(P<0.05)。雾化吸入后2组患儿呼吸、心率、血压、氧分压比较差异有统计学意义(P<0.05)。结论 3%氯化钠联合布地奈德及特布他林雾化吸入治疗婴幼儿体外循环术后气道痉挛疗效显著。值得临床推广应用。
Objective To observe the efficacy and safety of 3% sodium chloride combined with budesonide and terbutaline aerosol inhalation in the treatment of postoperative airway spasm of children with congenital heart disease（ CHD）.Methods From June 2011 to January 2013,47 cases of CHD patients underwent postoperative airway spasm After removal of the ventilator were selected and randomly divided into control group（ 22 cases） and observation group（ 25 cases）. The control group was given budesonide and terbutaline aerosol inhalation,while the observation group was added with 3% sodium chloride aerosol inhalation based on the control group. The symptom remission time,breathing,heart rate before and after inhalation,blood gas analysis（ PCO,PO2）,CICU residence time,re intubation ventilator or noninvasive CPAP children cases were analyzed. Results The shortness of breath relief,wheezing disappearance,wet rales disappearance time,CICU retention time,re intubation breathing machine or noninvasive CPAP children cases in the observation group were significantly less than the control group,the differences were statistically significant（ P 0. 05）. After atomization inhalation,the number of children whose PCO2 was below 50 mmHg was lower than that of the control group,the differences were statistically significant（ P 0. 05）.There were no significant differences in aspects of breathing,heart rate,blood pressure,oxygen partial pressure between 2groups after atomization inhalation（ P 0. 05）. Conclusion The effect of 3% sodium chloride combined with budesonide and terbutaline aerosol inhalation in the treatment of postoperative airway spasm of infants and young children with congenital heart is remarkable. It is worthy of clinical application.
出处
《临床合理用药杂志》
2014年第26期21-23,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
婴幼儿
体外循环
气道痉挛
呼吸治疗
Infants and young children
Cardiopulmonary bypass
Airway spasm
Respiratory therapy
