摘要
目的研究痰热清注射液联合抗菌药物治疗老年性脑卒中患者并发肺部感染的临床疗效与安全性,为临床治疗提供参考依据。方法选取2011年1月-2013年1月入院诊治的老年性脑卒中患者140例,随机分为试验组和对照组,各70例;对照组给予抗菌药物常规抗感染治疗,试验组则在对照组基础上应用痰热清注射液静脉滴注治疗;观察治疗后两组患者的治疗效果与安全性,治疗前后均应用功能独立性评定(FIM)评价两组患者的功能活动,数据采用SPSS16.0进行分析。结果试验组显效45例显效率64.28%,好转18例好转率25.71%,总有效率90.00%,对照组显效37例显效率52.85%,好转18例好转率25.71%,总有效率为78.57%;治疗后试验组轻度依赖占51.43%;中度占32.86%,重度占15.71%;对照组则分别占34.29%、38.57、27.14%;试验组FIM功能评价显著高于对照组,差异有统计学意义(P<0.05)。结论痰热清注射液联合抗菌药物治疗老年性脑卒中可显著改善临床症状,疗效显著,并且安全性高,可为临床提供一定的参考用药依据。
OBJECTIVE To study clinical efficacy and safety of Tanreqing combined with antibiotics for treatment of pulmonary infection in elderly stroke and provide reference for clinical data. METHODS Totally 140 elderly stroke patients hospitalized during Jan. 2011-Jan. 2013 were randomly divided into the experimental group （70 cases） and the control group （70 cases）. The control group received routine antiinfective therapy with antibiotics, while the experimental group received Tanreqing intravenous therapy based on routine antiinfective therapy. After treatment, the therapeutic efficacy and safety were observed in the two groups of patients, the functional inde- pendence measure （FIM） was used to evaluate functional activities in patients before and after treatment. Data were analyzed with SPSS 16.0. RESULTS The experimental group had 45 effective cases, with the markedly effective rate of 63,. 28%, and 18 improved cases, with the improvement rate of 25.71%, and the total effective rate was 90.00%. The control group had 37 effective cases, with markedly the effective rate of 52.85%, and 18 improved cases, with the improvement rate of 25.71%, and the total effective rate was 78.57 %. After treatment, the experimental group showed mild dependence in 36 cases, accounting for 51. 43%; moderate in 23 cases, accounting for 32.86% ; severe in 11 cases, accounting for 15.71%. The control group showed mild dependence in 24 cases, accounting for 34.29% ~ moderate in 27 cases, accounting for 38.57% ; severe in 19 cases, accounting for 27.14%. The experimental group had significantly higher FIM function evaluation than the control group. The defference of above data were significant （P〈0.05）. CONCLUSION Tanreqing and antibiotic treatment for senile stroke can significantly improve the clinical symptoms, with significant efficacy and safety, which can provide a reference for clinical medication.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第15期3709-3711,共3页
Chinese Journal of Nosocomiology
基金
内蒙古自治区自然科学基金项目(2011MS1102)
