摘要
目的探讨可溶性转铁蛋白受体(sTfR)对非成年人缺铁性贫血(IDA)的诊断价值及其与慢性病贫血(ACD)的鉴别诊断价值。方法 IDA组26例,男12例,女14例,年龄1月至15.5岁;ACD组33例,男17例,女16例,年龄2月至14.0岁;对照组30例,男15例,女15例,年龄1月至15.5岁。sTfR、铁蛋白(SF)检测方法为免疫比浊法,血清铁(SI)为亚铁嗪比色法。结果各组患儿的性别比例、年龄无显著性差异;ACD组的SI均值介于IDA组和对照组之间;IDA组的SF显著低于ACD组(P<0.001)和对照组(P<0.001),而sTfR显著高于ACD组(P<0.001)和对照组(P<0.001)。sTfR鉴别诊断IDA和ACD的截值为3.56mg/L,其敏感性、特异性、阴性预测值、阳性预测值、准确性分别为95.12%、93.92%、94.11%、97.53%、95.50%。结论sTfR对IDA具有较高的敏感性及特异性,有助于诊断IDA及鉴别诊断ACD。
Objective To investigate the diagnostic value of the soluble transferrin receptor （sTfR）in non-adult iron deficiency anemia （IDA）and its differential diagnostic value between IDA and anemia of chronic disease（ACD）.Methods 26 cases in the IDA group involved 12 males and 14 females,aged 1 month to 15.5 years;33 cases in the ACD group involved 17 males and 16 females, aged 2 months to 14.0 years;30 cases in the normal control group involved 15 males and 15 females,aged 1 month to 15.5 years. Serum sTfR and ferritin （SF）were detected by the immunonehelomitery,serum iron （SI）was detected by Ferrous Oxazine colori-metric method.Results The gender and age had no statistically significant difference among 3 groups;the SI mean value in the ACD group located between the IDA group′s and the normal control group′s;the SF mean value of the IDA group was significantly lower than that of ACD group （P 〈0.001）and that of control group （P 〈0.001）,while the sTfR mean value of IDA group was significantly higher than that of the ACD group （P 〈0.001）and that of the normal control group （P 〈0.001）.The best cutoff of sTfR for the differential diagnosis between IDA and ACD was 3.56 mg/L,its sensitivity,specificity,negative predictive value,posi-tive predictive value and accuracy were 95.12%,93.92%,94.11%,97.53% and 95.50% respectively.Conclusion sTfR has higher sensitivity and specificity for IDA and is conducive to diagnose IDA and differentially diagnose ACD.
出处
《国际检验医学杂志》
CAS
2014年第14期1885-1886,共2页
International Journal of Laboratory Medicine
关键词
非成年人
受体
转铁蛋白
诊断
缺铁性贫血
慢性病贫血
non-adult
transferring receptor
diagnosis
iron deficiency anemia
anemia of chronic disease
