摘要
报道了异长春花苷内酰胺在水溶液中经自然光照射后,发生光氧化反应,主要降解产物为(3S)-短小蛇根草苷.采用通入氧气和日光灯照射的方法可加速异长春花苷内酰胺光降解,(3S)-短小蛇根草苷的产率为56%.
Photochemical reaction in the water solution of And the main degradation product, （3S） -pumiloside, was stictosamide was studied by HPLC and LC-MS. isolated and identified by 1H NMR, 13C NMR, HRMS and optical rotation. The fragmentation patterns of （3S）-pumiloside and other intermediates were ana- lysed by LC-MS. And then the mechanism of the strictosamide transformation into （3S）-pumiloside by light with O2 was also analysed. To improve the productivity of （3S）-pumiloside, the sunlight was replaced by light of fluorescent lamps. The productivity of （3S）-pumiloside was improved to 56% using light of fluorescent lamps and adding O2 into the stictosamide solution for accelerating degradation. This discovery shows a new green way to make the （3S）-pumiloside, and provided references for the structure transformation of similar compounds. This also gave the evidence that the strictosamide need to be stored against light.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2014年第8期1710-1714,共5页
Chemical Journal of Chinese Universities
基金
国家'十二五'重大新药创制项目(批准号:2012ZX09102201-017)资助~~
