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七氟烷不损害行腹腔镜下胆囊切除术的65岁以下成年患者术后早期精神运动功能 被引量:3

Sevoflurane anesthesia causes no psychomotor dysfunction early after laparoscopic cholecystectomy in adult patients under 65 years
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摘要 目的比较七氟烷与丙泊酚麻醉对行腹腔镜下胆囊切除术(LC)患者术后早期精神运动功能的影响。方法60例美国麻醉医师学会(ASA)分级Ⅰ或Ⅱ级、年龄18~65岁、择期行LC的患者,随机分入丙泊酚组和七氟烷组,每组30例。分别于术前1d(T1)、术后2d(T2)进行神经心理学测试,包括数字连接试验A(NCT—A)、轨迹描绘试验(LTT)、系列打点试验(SDT)、数字符号试验(DST)。结果两组间同时间点的NCT—A、LTT、SDT、DST评分的差异均无统计学意义(P值均〉0.05)。两组在T2时间点的NCT-A评分均显著低于同组T1时间点(P值〈0.05),DST评分均显著高于同组T1时间点(P值均〈0.05),LTT和SDT评分与同组T1时间点的差异均无统计学意义(P值均〉0.05)。结论丙泊酚和七氟烷对行LC患者术后早期均未造成精神运动功能损害。 Objective To compare the anesthetic effect of sevoflurane with propofol on early psychomotor function after laparoscopic cholecystectomy. Methods A total of 60 patients aged 18-65 years, American Society of Anesthesiologists (ASA) physical status Ⅰ or Ⅱ,scheduled for laparoscopic cholecystectomy were randomly divided into propofol group and sevoflurane group (n = 30 in each). The psychomotor function evaluation was performed on 1 day before operation (T1) and 2 days after operation (T2) with four neuropsychological tests, including number connection test A (NCT-A), line tracing test (LTT), serial dotting test (SDT) and digit symbol test (DST). Results There were no significant differences in the neuropsychological test scores between groups at T1 or T2 (all P〉0.05). Compared with the values at T1, the scores of NCT-A were significantly decreased and DST scores were significantly increased at T2 in both groups (all P〈0.05) ; while the differences of LTT and SDT results had no significant differences (all P〉0.05, T2 vs. T1 ). Conclusion Similar to propofol, sevoflurane does not cause psychomotor dysfunction early after laparoscopic cholecystectomy.
出处 《上海医学》 CAS CSCD 北大核心 2014年第6期479-481,共3页 Shanghai Medical Journal
基金 国家自然科学基金青年项目资助(81100276)
关键词 精神运动性行为 腹腔镜胆囊切除术 认知功能 全身麻醉药 七氟烷 丙泊酚 Psychomotor performance Laparoscopic cholecystectomy Cognitive function Generalanesthetic Sevoflurane Propofol
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参考文献10

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