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阿霉素治疗实验性外伤性增生性玻璃体视网膜病变

Therapeutic effect of adriamycin on the experimental traumatic proliferative vitreoretinopathy
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摘要 目的:观察玻璃体腔注射阿霉素治疗外伤性增生性玻璃体视网膜病变(proliferative vitreoretinopathy,PVR)的效果;同时观察玻璃体腔细胞因子含量的变化。方法:建立外伤性PVR动物模型。随机分为生理盐水组、阿霉素组。直接眼底镜观察PVR程度;酶联免疫吸附法(enzyme-liked immunosorbent assay,ELIsA)测定玻璃体腔白介素-lβ(Interleukin-lβ,IL-lβ)、转化生长因子βl(transforming growth factor-beta 1,TGF-β1)浓度。结果:阿霉素组PVR程度、玻璃体腔IL-lβ浓度、转化生长因子βl浓度低于生理盐水组。结论:玻璃体腔注射阿霉素可以降低外伤性PVR程度,同时下调玻璃体腔IL-lβ、TGF-βl浓度。 Objective: To observe the therapeutic effect of the intravitreal injection of adrimycin on the experimental traumatic proliferative vitreoretinopathy(PRV), and the concentranon changes of cytokines in the vitreous cavity. Methods. ' Animal models of traumatic PVR were established, which were randomized into the normal saline group(NS group) and adriamyein group. The degrees of proliferative vitreoretinopathy were estimated by direct ophthalmoscope examination; the concentration of IL-1βand TGF-β1in the vitreous cavity was detected by enzyme-liked immun0sorbent assay(ELIsA). Results= The degree of PRV, concentration of IL-lβ and TGF-β1, in the vitreous cavity in the adriamycin group are lower than that of the NS group. Conclusion:The intravitreal in jection of adriamycin can decrease the degrees of PVR and the concentration of IL-1β and TGF-β1.
出处 《华夏医学》 CAS 2014年第4期41-43,共3页 Acta Medicinae Sinica
基金 广西自然科学基金资助(桂科自0640191)
关键词 外伤 增生性玻璃体视网膜病变 阿霉素 external injury proliferative vitreoretinopathy adriamycin
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