摘要
目的观察中西医结合治疗(西医基础治疗+活心丸)对稳定型心绞痛患者心功能的改善及血压等指标的影响。方法按照配对设计的方法,以年龄、性别、身体质量指数、血压作为配对条件,将30例稳定型心绞痛患者分为西药常规治疗组(Ⅰ组)与中西医结合治疗组(Ⅱ组),每组各15例。Ⅰ组患者口服阿司匹林100 mg 1/日,倍他乐克50 mg 1/日,阿托伐他汀10 mg 1/日治疗;Ⅱ组患者在Ⅰ组治疗方案的基础上加用活心丸3粒1/日口服。治疗8周后,比较两组患者在治疗前后心功能、血压、血脂与同型半胱氨酸等指标的变化情况。结果两组患者治疗8周后与治疗前比较,Ⅰ组患者中舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)水平均有下降的趋势,其中DBP具有统计学差异(P<0.05);Ⅱ组患者中治疗后左室射血分数(LVEF)与左室短轴缩短分数(LVFS)水平较治疗前明显升高,具有显著统计学差异(P<0.01);SBP、DBP、TG、TC、LDL-C、Hcy水平较治疗前有下降的趋势,其中治疗前后SBP、Hcy水平具有统计学差异(P<0.05)。两组患者各指标治疗前后差值比较显示,SBP、LVEF、LVFS差值比较具有统计学意义(P<0.05)。结论中西医结合治疗(西医基础治疗+活心丸)可改善稳定型心绞痛患者心功能,并能显著降低收缩压,相对于单纯西药常规治疗具有一定优势。
Objective To observe the influences of therapy integrated Chinese and Western medicine （Western basic treatment combining Huoxin Wan） on heart function and blood pressure （BP） in patients with stable angina pectoris （SAP）. Methods According to age, sex, BMI and BP, 30 patients with SAP were divided into group treated with routine Western drugs （group I） and group treated with therapy integrated Chinese and Western medicine （group II, each n=15） by using paired design method. Group I was orally given aspirin （100 mg/d）, betaloc （50 mg/d） and atorvastatin （10 mg/d）, and group II was additionally given Huoxin Wan （3 pieces a day）. After 8 w, the changes of heart function, BP, blood fat and homocysteine （Hcy） were compared in 2 groups before and after treatment. Results After treatment for 8 w, the levels of diastolic blood pressure （DBP）, TG, TC, LDL-C and Hcy trended to decrease, and DBP had statistical difference （P〈0.05） in group I. The levels of LVEF and LVFS increased significantly, levels of systolic blood pressure （SBP）, DBP, TG, TC, LDL-C and Hcy trended to decreased, and levels of SBP and Hcy had statistical difference （P〈0.05） in group I. The comparison in the difference of all indexes before and after treatment showed that the difference in SBP, LVEF and LVFS had statistical significance （P〈0.05）. Conclusion The therapy integrated Chinese and Western medicine （Western basic treatment combining Huoxin Wan） can improve heart function and reduce SBP significantly, which has more advantages compared with Western routine treatment.
出处
《中国循证心血管医学杂志》
2014年第3期346-348,351,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
稳定型心绞痛
活心丸
心功能
收缩压
Stable angina pectoris
Huoxin Wan
Heart function
Systolic blood pressure
