摘要
目的:探讨宫颈鳞癌组织中整合素α5β1蛋白和乙酰肝素酶蛋白表达及临床意义。方法:应用组织芯片技术结合免疫组化方法 (SP法)检测68例宫颈鳞癌组织和20例宫颈正常组织整合素α5β1蛋白和乙酰肝素酶蛋白表达情况,分析两者在宫颈鳞癌组织中表达的相关性。结果:宫颈鳞癌组织整合素α5β1蛋白和乙酰肝素酶蛋白的阳性表达率分别为77.9%和72.1%,均高于正常宫颈组织中的表达,差异有统计学意义(P<0.05);整合素α5β1蛋白和乙酰肝素酶蛋白在宫颈鳞癌组织中的表达呈正相关关系(r=0.570)。结论:整合素α5β1蛋白和乙酰肝素酶蛋白的高表达与宫颈鳞癌的发生、发展有关,并且具有正协同作用。
Objective： To explore the expressions of integrin α5β1 protein and heparanase protein in cervical squamous cell carcinoma and the clinical significanees. Methods： Tissue microarray combined with immunohistoehemical SP method was used to detect the expressions of integrino α5β1 protein and heparanase protein in 68 cases with cervical squamous cell carcinoma and 20 cases with normal cervix, the correlation of integrin α 5β protein and heparanase protein expressions in cervical squamous cell carcinoma was analyzed. Results： The positive expression rates of integrin α5β1 protein and heparanase protein in cervical squamous cell carcinoma were 77.9% and 72. 1%, respectively, which were statistically significantly higher than those in normal cervical tissue （P 〈 0.05） ; there was a positive correlation between integrin α5β1 protein expression and heparanase protein expression in cervical squamous cell carcinoma （r = 0. 570） . Conclusion： High expressions of integrin α5β1 protein and heparanase protein are correlated with the occurrence and development of cervical squamous cell carcinoma, and there is a positive synergistic effect.
出处
《中国妇幼保健》
CAS
北大核心
2014年第22期3665-3667,共3页
Maternal and Child Health Care of China
基金
河北省计生委指令性课题〔2012-A21〕
关键词
宫颈鳞癌
整合素
α5β1
乙酰肝素酶
组织芯片
Cervical squamous cell carcinoma
Integrin α5β1
Heparanase
Tissue microarray
