摘要
目的:考察美罗培南与复方氯化钠注射液、复方乳酸钠葡萄糖注射液、乳酸钠林格注射液3种输液的配伍稳定性,为临床合理配伍提供依据。方法:采用高效液相色谱法测定美罗培南含量。取注射用美罗培南加入复方氯化钠注射液、复方乳酸钠葡萄糖注射液、乳酸钠林格注射液3种输液中放置8 h,分别于0、1、2、4、8 h时考察配伍液的外观、不溶性微粒、pH、美罗培南含量的变化。结果:在8 h内,配伍液外观、pH、不溶性微粒均无明显变化,符合《中国药典》相关规定;美罗培南含量在4 h内无明显变化,但8h时含量下降。结论:美罗培南若与3种输液配伍使用,应现配且尽快用完。
OBJECTIVE ： To investigate the compatible stability of meropenem combined with Compound sodium chloride injection, Compound sodium lactate and glucose injection and Sodium lactate Ringer＇s injection, and to provide reference for reasonable clinical compatibility. METHODS： The content of meropenem was determined by HPLC. Meropenem for injection was added into Compound sodium chloride injection, Compound sodium lactate and glucose injection and Sodium lactate Ringer＇s injection; the change of appearance, insoluble particle and pH of mixture, and the content of meropenem were investigated at 0, 1, 2, 4 and 8 h. RESULTS ： The appearance, insoluble particle and pH of mixture had no significant change within 8 h, which was in line with the requirements of Chinese Pharmacopeia; the content of meropenem had no significant change within 4 h but decreased at 8 h. CONCLUSIONS ： The mixture of meropenem combined with 3 kinds of injections should be used out as soon as possible.
出处
《中国药房》
CAS
CSCD
2014年第29期2764-2766,共3页
China Pharmacy
