摘要
目的探讨铍针对皮神经卡压大鼠5-HT、PGE1、PGF2α的影响。方法 Wistar大鼠60只,随机分成3组,A组:隐神经不做任何处理;B组:以内径0.3 mm的硅胶管卡压隐神经;C组:以内径0.5 mm的硅胶管卡压隐神经。造模成功1个月后,每组取10只测定机体自身所分泌的5-HT、PGE1、PGF2α的浓度,对每组余下10只:A组不做治疗,对B、C组进行铍针治疗,治疗后测定机体自身所分泌的致痛因子5-HT、PGE1、PGF2α的浓度。结果造模1个月后B、C组致痛因子5-HT、PGE1、PGF2α的浓度明显高于A组,差异有统计学意义,经铍针治疗后B、C组致痛因子5-HT、PGE1、PGF2α的浓度同A组比较差异无统计学意义。结论铍针治疗皮神经卡压性疼痛疗效在临床上已得到验证,通过实验证明其通过抑制机体释放降低痛阈的物质达到此疗效。
Objective To investigate the effect of stiletto needle on 5-HT、PGE1 and PGF2α of rats with cutaneous nerve entrapment. Methods 60 Wistar rats were divided into 3 groups. Group A: the saphenous nerve,no treatment;Group B: with the diameter of 0. 3 mm silica gel tube clamp pressure saphenous nerve; Group C: with the diameter of0. 5 mm silica gel tube clamp pressure saphenous nerve. After one month of modeling,10 rats of each group were selected. Their bodies' secretion of 5-HT、PGE1 and PGF2α were detected. For the rest: no treatment in Group A; stiletto needle therapy for Group B and C. Their bodies' secretion of 5-HT、PGE1 and PGF2α were also detected after treatment. Results After one month of modeling,the concentrations of induced pain factors of 5-HT、PGE1、PGF2α in Group B and C were significantly higher than those in Group A. There was statistical significance. After two months by stiletto needle treatment,concentrations of induced pain factors of 5-HT、PGE1、PGF2α in Group B and C had no statistical significance compared with group A. Conclusion The effect of stiletto needle for cutaneous nerve entrapment had good effect. Moreover,the experiments proved that it can inhibit the release of painful substance.
出处
《吉林中医药》
2014年第7期713-715,共3页
Jilin Journal of Chinese Medicine
基金
国家自然科学基金"铍针治疗皮神经卡压性疼痛的机理研究"(81072822)
