摘要
目的:观察依达拉奉对脑梗死患者Th1/Th2及红细胞免疫的影响。方法:将120例急性脑梗死患者随机分成两组,对照组和观察组各60例,对照组采用基础治疗,观察组加载依达拉奉注射液治疗。比较治疗前后两组间T淋巴细胞亚群及细胞因子γ-干扰素(IFN-γ)、白介素-2(IL-2)、白介素-4(IL-4)、白介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)水平及红细胞免疫功能差异。结果:治疗第7、14天,观察组与对照组比较,CD3+、CD4+淋巴细胞百分比和CD4+/CD8+均上升,CD4+CD25+调节性T淋巴细胞则下降;观察组血清IFN-γ、IL-2和TNF-α水平低于对照组,IL-4、IL-10则高于对照组;观察组红细胞C3b受体花环(RBC-c3bRR)和红细胞免疫粘附促进因子(RFER)高于对照组,RBC-ICR和RFIR则明显低于对照组,差异均有统计学意义(P<0.05)。结论:脑梗塞患者加载依达拉奉治疗后,Th1/Th2淋巴细胞失衡和红细胞免疫功能得到了改善,依达拉奉有利于促进疾病的康复。
Objective.. To observe the influence of edaravone for the Thl/Th2 and erythrocyte immune of patients with cerebral infarction. Methods..A total of 120 patients with cerebral infarction were randomly divided into control group and observation group, with 60 cases in each group. Then the T lymphocyte subsets serum levels of IFN-γ, IL-Z, IL-4, IL-10 and TNF-α,and the function of erythrocyte immune of two groups before and after treatment were compared. Results： After7,14 days of treatment, the percentages of CD3＋ and CD4＋ and CD4＋/CD8＋ of observation group were higher than control group, and CD4＋ , CD25＋ was lower than control group; the serum levels of IFN-γ IL-2 and TNF-γ of observation group were lower than control group,and the IL-4 and IL-10 was higher than control group; the indexes of RBC-C3bRR and RFER were higher than control group, the indexes of RBC-ICR and RFIR were lower than control group （P all%0.05）. Conclusion.. Patients with cerebral infarction treat by edaravone can effectively improve the imbalance of Th1/Th2 and lymphocyte and the function of erythrocyte immune, and it can promote the rehabilitation of the disease.
出处
《海南医学院学报》
CAS
2014年第9期1286-1288,共3页
Journal of Hainan Medical University
基金
荆州市卫生局资助基金(20182273)~~
关键词
脑梗死
依达拉奉
T淋巴细胞
红细胞免疫
Cerebral infarction
Edaravone
Tlymphocyte
Erythrocyte immune
