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急性脑梗死患者颈动脉内-中膜与炎症因子IL-18和脂联素的关系分析 被引量：5

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摘要 目的通过研究颈动脉内-中膜厚度(IMT)与血清细胞因子白介素(IL-18)、脂联素的水平的关系,探讨IMT增厚的机制。方法选择64例急性脑梗死(ACI)患者和30名健康志愿者作为研究对象,并分为IMT<1.0 mm亚组和IMT>1.0 mm亚组。酶联免疫吸附法(ELISA法)测定血清IL-18、脂联素水平,分析IMT与IL-18、脂联素的相关性。结果脑梗死组IMT≥1.0 mm者IMT与IL-18水平呈正相关(r=0.543,P<0.01),与脂联素呈负相关(r=-0.594,P<0.01)。IMT<1.0 mm者IMT与血清脂联素、IL-18水平无明显相关性(r=0.241、0.191,P均>0.05)。结论脑梗死颈动脉IMT>1.0mm者血清IL-18水平升高,脂联素水平降低,动脉内膜增厚可能与IL-18和脂联素的比例失调有关。
作者 韩亚州 张洋 闫军
机构地区 河南沁阳市人民医院内三科
出处 《中国实用神经疾病杂志》 2010年第22期42-43,共2页 Chinese Journal of Practical Nervous Diseases
关键词 动脉粥样硬化 内-中膜厚度 白介素-18 脂联素
分类号 R74 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

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共引文献29

同被引文献42

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二级引证文献33

中国实用神经疾病杂志
2010年 第22期

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