摘要
目的探讨2型糖尿病、血脂水平与颈动脉硬化的关系。方法选取150名疗养的离退休干部为对象,其中63例患有2型糖尿病为糖尿病组,87名无糖尿病者为对照组,分别进行血糖、血脂相关指标检测,用彩色多普勒超声对颈动脉血管进行检查,并进行单因素对比分析;采用多元线性回归方法分别对两组的颈动脉硬化程度评分与检测的各项血脂指标作分析,评价两者的相关性。结果糖尿病组总胆固醇(TCH)、三酰甘油(TG)、低密度脂蛋白(LDL)、载脂蛋白B(ApoB)水平均高于对照组(P<0.05)。两组的颈动脉超声均显示有不同程度硬化表现,但糖尿病组的颈动脉硬化程度、斑块检出率及累及多支血管检出率均高于对照组(P<0.05)。两组间血流峰值流速在颈总动脉和颈内动脉的差异有统计学意义(P<0.01)。颈动脉硬化程度评分与检测的各项血脂指标间的多元线性回归分析显示,糖尿病组的复相关系数为0.870(P<0.01),对照组为0.902(P<0.01),两组结果均说明颈动脉硬化程度与血脂水平存在相关。结论高血脂是2型糖尿病患者血管病变的重要促进因素;颈动脉超声检查是早期发现糖尿病患者血管病变的较好检查手段。
Objective To evaluate the relationship between type II diabetes,hyper lipid level and carotid artery arthrosclerosis by ultrasonography. Methods A total of 150 retired officers were selected,of which 63 diabetic patients were divided into case group while 87 subjects free of diabetes were divided into control group. Blood laboratory examination was conducted and the manifestation of carotid artery was examined by ultrasonography. Results TCH,TG,LDL and ApoB of case group were significantly higher than those in control group（ P〈0. 05）. The intimamedia thickness（ IMT） of carotid artery in case group was increased significantly（ P〈0. 05）. Moreover,arteries narrowing and plaque were more than those in control group（ both P〈0. 05）. T peak velocity in carotid artery and internal carotid were of statistical significance between two groups（ P〈0. 01）. Furthermore,multiple linear regression analysis considering the degree of carotid artery arthrosclerosis and serum lipid showed that multiple correlation coefficient of case group was 0. 870（ P〈0. 01） and 0. 902（ P〈0. 01） of control group. Conclusion Hyperlipidemia may have the promote effect on the formation of arteriosclerosis plaque and ultrasonography could be one of the effective methods to detect early vessel lesion of diabetic patients.
出处
《浙江预防医学》
2014年第7期671-674,共4页
Zhejiang Journal of Preventive Medicine
关键词
2型糖尿病
超声检查
颈动脉
血脂水平
Type 2 diabetes mellitus
Ultrasonography
Carotid arteries
Serum lipid level
