摘要
目的:研究参附注射液治疗舒张性心力衰竭的临床疗效并探讨其可能的作用机制。方法:舒张性心力衰竭患者分为两组:常规治疗组和参附注射液组。常规治疗组给予常规基础治疗,参附注射液组患者在常规基础治疗上加用参附注射液治疗,疗程为2周,每日1次,每次60ml静脉滴注。评价两组患者治疗前、后心功能改善情况,中医证候积分,检测血浆中脑钠肽前体氨末端(NT-proBNP)、Ⅲ型前胶原氨基端肽(PⅢP)、层粘连蛋白(LN)、血浆醛固酮(ALD)含量,行心脏彩超相关指标检测。结果:两组患者治疗后心功能、中医证候积分均显著优于治疗前,超声心动图参数LA、LVEDd、LVEDs、LVPWD、E/A均较治疗前显著改善。血浆NT-proBNP、PⅢP、LN、ALD水平均显著降低。与常规治疗组比较,参附注射液组患者上述各指标改善具有显著性差异。结论:参附注射液治疗舒张性心力衰竭机制可能与改善心肌重构、抑制神经内分泌过度激活有关。
To study the clinical effect and the probable mechanism of Shenfu injection in the treatment of diastolic heart failure. Meth- od： 60 cases of patients with diastolic heart failure were randomly divided into 2 groups, conventional therapy group and Shenfu injection therapy group. Patients in conventional therapy group were treated with diuresis, angiectasis, angiotensin-converting enzyme inhibitors and 13 -blockers. Patients in Shenfu injection therapy group were treated with Shenfu injection on the basis of conventional therapy. The course of treatment was 2 weeks. The improvement of cardiac function, TCM syndrome score was evaluate before and after treatment, as well as the content of NT-proBNP, m procollagen amino- terminal propetide, Laminin and Aldosterone in Plasma was measured. Left atrial diameter （ LA）, 1 eft ventricular end-diastolic diameter （ LVEDD）, 1 eft ventricular end-systolic diameter （ LVESD）, inter-ventricular septal diameter （IVSD） ,left ventricular posterior wall diameter（LVPWD） and E/A was measured by echocardiography. Result： Compared with before- treatment, cardiac function and TCM syndrome score was significantly better（ P 〈 0.05）, plasma levels of NT-proBNP, P llI P, LN and ALD was significantly decreased（ P 〈 0.05）. Echocardiographic parameters as LA, LVEDD, LVESD, LVPWD and E/A was significantly reduced （ P 〈 0.05 ）. Compared with conventional therapy group, the above indicators in patients in Shenfu injection group was significantly improved （ P 〈 0.05 ）. Conclusion： The therapeutic effects of Shenfu injection is remarkable, so it is worth promoting in clinical. The probable mech- anism of the effect may Possibly through improving myocardial remodeling and suppressing excessive activation of neuroendocrine.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第4期116-119,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
江西省卫生厅科研基金
编号2011A01
关键词
参附注射液
舒张性心力衰竭
心肌重构
神经内分泌
Shenfu Injection（参附注射液）
diastolic heart failure
myocardial remodeling
neuroendocrin
