摘要
目的系统评价RUNX3在结直肠癌中的表达水平及其与临床特征的相关性。方法计算机检索PubMed、The Cochrane Library（2013年第9期）、EMbase、MEDLINE（Ovid）、CNKI、VIP、WanFangData和CBM，查找周内外公开发表的RUNX3表达与结直肠癌及其临床特征关系的病例一对照研究，检索时限均为从建库至2013年10月1日。由2位研究者根据纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后，采用RevMan5．2软件进行Meta分析。结果最终纳入7个病例一对照研究，共计804例，其中结直肠癌病例521例，对照383例。Meta分析结果显示：RUNX3表达在结直肠癌组织低于癌旁正常组织[OR=0．05，95％CI（O．03，O．08），P〈0．00001]；高中分化组结直肠癌的RUNX3表达高于低分化组结直肠癌[OR=4．77，95％CI（2．88，7．90），P〈0．00001]；浸润深度T1-T2期结直肠癌的RUNX3表达高于T3～T4期结直肠癌[OR=8．13，95％CI（4．15，15．92），P〈0．00001]；伴淋巴结转移的结直肠癌RUNX3表达低于无淋巴结转移的结直肠癌[OR=0．23，95％CI（o．14，0．36），P〈0．00001]，其差异均有统计学意义。而不同年龄、性别及不同部位结直肠癌患者癌组织中RUNX3表达无明显差异。结论RUNX3蛋白的表达与结直肠癌及其不同临床特征有显著相关性。受纳入研究数量和质量限制，上述结论尚待开展更多高质量研究加以验证。
Objective To systematically review the correlation between RUNX3 expression of colorectal cancer and its clinical characteristics. Methods Databases including PubMed, The Cochrane Library （Issue 9, 2013）, EMbase, MEDLINE （Ovid）, CNKI, VIP, WanFang Data and CBM were searched for collecting published international and domestic case-control studies on the correlation between RUNX3 expression of colorectal cancer and its clinical characteristics from the date of their establishment to October 1st, 2013. Two reviewers screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of the included studies. Then, meta-analysis was performed using RevMan 5.2 software. Results A total of 7 case-control studies were included involving 804 cases in total （521 cases in colorectal cancer group and 383 cases in control group）. The results of meta-analysis showed that, RUNX3 expression was lower in the colorectal cancer group than in the normal control group （OR=0.05, 95%CI 0.03 to 0.08, P〈0.000 01）; higher in the moderately/highly-differentiated group than in the poorly differentiated group （OR=4.77, 95%CI 2.88 to 7.90, P〈0.000 01）; higher in colorectal cancer with invasion depth on T1-T2 stage than in that on T3-T4 stage （OR=8.13, 95%CI 4.15 to 15.92, P〈0.000 01）; and lower in the colorectal cancer accompanied with lymph node metastasis than that without lymph node metastasis （OR=0.23, 95%CI 0.14 to 0.36, P〈0.000 01）, all with significant differences. No significant difference was found in RUNX3 expression between groups by age, sex and tumour location. Conclu- sion RUNX3 expression is notably correlated to colorectal cancer and its clinical characteristics. Due to the quantity and quality limitation of the included studies, the above conclusion still needs to be further proved by performing more high quality studies.
出处
《中国循证医学杂志》
CSCD
2014年第7期806-812,共7页
Chinese Journal of Evidence-based Medicine
基金
四川省科技支撑计划(编号:2013SZ0081)
