摘要
目的：研究多巴胺、硝酸甘油、呋塞米联合应用在慢性心肾综合征患者中的疗效。方法：选取2011年7月～2013年7月住院的慢性心肾综合征患者74例，随机分为实验组40例，对照组34例。对照组按照心衰指南常规治疗，实验组在常规治疗基础上予以多巴胺5μg· kg^-1/min，硝酸甘油5μg· kg^-1/min，呋塞米0.5 mg/kg静脉泵入，每日2次，疗程1周。观察治疗前后两组患者的左室射血分数（ LVEF）值、左室舒张末期内径（ LVD d）、 N末端脑钠肽前体（ NT-pro BNP）以及血肌酐（sCr）、肾小球滤过率（GFR）等指标。结果：治疗后LVD d和NT-pro BNP有不同程度下降， LVEF有所升高。实验组优于对照组（ P＜0.05， P＜0.01）。经治疗后两组患者胱抑素-C、 sCr下降， GFR提高，实验组优于对照组（P＜0.05， P＜0.01）。结论：慢性心肾综合征患者在常规心衰治疗基础上联合使用多巴胺、硝酸甘油、呋塞米对心肾功能改善更好。
OBJECTIVE： To investigate the efficacy of Dopamine combined with Nitroglycerin and Furosemide in Chronic Cardio-renal Syndrom .METHODS： 74 Cases were selected from July 2011 to July 2013 in hospitalized patients with Chronic Cardiorenal Syn-drom and were divided into experimental group （n=40） and the control group （n=34） randomly.The control group received con-ventional treatment according to guide -lines and the experimental group accepted Dopamine （5μg· kg-1/m-1）, Nitroglycerin （5μg· Kg-1/m-1） and Furosemide （0.5 mg/kg-1, intravenous infusion, twice daily, for one week.Observation index included LVEF, LVD d, NT-pro BNP, sCr and GFR et al .RESULTS： LVD d and NT-pro BNP were reduced but LVEF was raised in each group after treatment .The level of sCr and CYSC were reduced and GFR was increased in each group .The levels in the experi-mental group improved significantly than those in the control group （P〈0.05, P〈0.01）.CONCLUSION： Dopamine combined with Nitroglycerin and Furosemide can improve the function of heart and kidney in the Chronic Cardiorenal Syndrom .
出处
《国际老年医学杂志》
2014年第4期155-156,F0003,共3页
International Journal of Geriatrics
关键词
多巴胺
硝酸甘油
呋塞米
心肾综合征
治疗
Dopamine
Nitroglycerin
Furosemide
Cardiorenal Syndrome
Therapy
