摘要
目的探讨参麦注射液联合呋塞米与多巴胺对慢性肺源性心脏病伴左心力衰竭患者血清脂联素(APN)、和肽素(CPN)、白细胞介素-6(IL-6)水平及心功能的影响。方法选取2018年11月至2020年9月在淄博市博山区中医院就诊的慢性肺源性心脏病伴左心力衰竭患者60例作为研究对象,按随机数字表法分为对照组与观察组,各30例。对照组采用呋塞米与多巴胺治疗,观察组在对照组治疗基础上加用参麦注射液治疗。比较两组临床疗效、APN、CPN、IL-6、肺功能及心功能。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组APN水平高于治疗前,CPN、IL-6水平低于治疗前,且观察组上述指标变化幅度大于对照组,差异有统计学意义(P<0.05);治疗后,两组最大呼气峰流速(PEF)、第一秒钟用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组治疗后美国纽约心脏病协会(NYHA)分级优于对照组,差异有统计学意义(P<0.05)。结论慢性肺源性心脏病伴左心力衰竭患者采用参麦注射液联合呋塞米与多巴胺治疗的效果较好,可有效改善患者血清APN、CPN、IL-6水平、肺功能及心功能。
Objective To investigate the effects of Shenmai injection combined with furosemide and dopamine on serum levels of human adiponectin(APN), human copeptin(CPN) and interleukin-6(IL-6) and heart function in patients with chronic pulmonary heart disease with left heart failure. Methods A total of 60 patients with chronic pulmonary heart disease with left heart failure who were treated in the Boshan District Hospital of Traditional Chinese Medicine in Zibo City from November 2018 to September 2020 were selected as research objects and were divided into a control group and an observation group with 30 cases in each group by random number table method. The control group was treated with furosemide and dopamine, and the observation group was treated with Shenmai injection plus furosemide and dopamine. The clinical efficacy, serum APN, CPN, IL-6, lung function and heart function were compared between the 2 groups. Results The total treatment effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05);after treatment, the APN levels of the 2 groups were higher than those before treatment, and the levels of CPN and IL-6 were lower than those before treatment. The range of changes in the above indicators in the observation group was greater than that in the control group, and the difference was statistically significant(P<0.05);after treatment, the peak respiratory flow rate(PEF), forced respiratory volume in the first second(FEV1) and forced vital capacity(FVC) levels of the 2 groups were higher than those before treatment, and the observation group was higher than the control group, the difference was statistically significant(P<0.05);the NYHA heart function classification of the observation group was better than the control group after treatment, and the difference was statistically significant(P<0.05).Conclusion The effects of Shenmai Injection combined with furosemide and dopamine in patients with chronic pulmonary heart disease with left h
作者
亓恒梁
QI Heng-Liang(Department of Cardiology,Boshan District Hospital of Traditional Chinese Medicine,Zibo City,Zibo 255200,China)
出处
《中国药物经济学》
2021年第10期83-86,共4页
China Journal of Pharmaceutical Economics
关键词
慢性肺源性心脏病
心力衰竭
参麦注射液
呋塞米
多巴胺
心功能
Chronic pulmonary heart disease
Heart failure
Shenmai Injection
Furosemide
Dopamine
Heart function
