摘要
目的:探讨益肾健脾汤对慢性萎缩性胃炎大鼠骨密度及钙、磷含量影响的实验研究。方法:大鼠以饮用0.1%氨水建立慢性萎缩性胃炎(CAG)模型,治疗90d后应用双能X线吸收法(DEXA)检测大鼠股骨骨密度,应用全自动生化分析仪检测钙、磷等骨代谢生化指标,对结果进行比较。结果:与正常对照组比较,造模后各组大鼠股骨骨密度值显著降低(P<0.05);血清总钙、骨钙素均降低(P<0.05);血清无机磷均升高(P<0.05)。与模型组相比,中药干预三组均有明显改善(P<0.05)。结论:益肾健脾汤对慢性萎缩性胃炎模型大鼠伴骨质疏松症有良好的治疗作用,能改善骨密度和骨矿含量,其机理可能是其增加钙吸收及BGP分泌,降低血清P,抑制骨吸收,促进骨形成,从而改善骨质疏松的发生。
Objective： To explore the effects of gastrectomy on bonemineral density and calcium and phosphorus in chronic atrophic gastritis rats. Methods ： The rats CAG model was established with O. 1% ammonia water. After 90 days treatment, DEXA was adopted to detect rat femur BMD, and automatic biochemical analyzer was used to detect calcium and phosphorus. Results： Compared with control group, the rats with chronic atrophic gastritis had a significant decrease of Ca, BGP, femoral BMD and BMC, and increase of P （ P 〈 0. 05）. Compared to model group, the Chinese drug treat- ment group relieved all changes （ P 〈 0.05 ）. Conclusion： The Chinese drug Yishen Jianpi Decoction has good curative effect on chronic atrophic gastritis with osteoporosis model rats, and it also can significantly improve femoral BMD and BMC in rats. Its mechanism may be related with increasing intestinal absorption of calcium and BGP secretion as well as lower P.
出处
《中华中医药学刊》
CAS
2014年第7期1740-1741,共2页
Chinese Archives of Traditional Chinese Medicine
基金
青岛市中医科研计划项目(2009-zyw032)
