摘要
目的探讨针灸联合加味香砂六君子汤对脾胃虚弱型慢性萎缩性胃炎患者中医证候、组织学及疗效的影响。方法选取诊治的脾胃虚弱型慢性萎缩性胃炎患者120例,随机分为对照组与观察组,每组60例,两组均给予西药为基础治疗,对照组给予加味香砂六君汤治疗,观察组给予针灸联合加味香砂六君子汤治疗,观察治疗前后中医证候积分变化及胃镜下组织学变化,对治疗疗效进行评定。结果两组患者治疗前胃部喜按喜暖、胃脘胀满或隐痛、大便稀溏、乏力、气短懒言、纳呆少食等症候积分比较差异无统计学意义(P>0.05),治疗后积分较治疗前均下降(P<0.05),且观察组下降幅度大于对照组(P<0.05);两组患者治疗前胃镜下腺体萎缩、肠上皮化生、慢性炎症、异型增生、病变活动度严重程度评分比较差异无统计学意义(P>0.05),治疗后上述组织学指标评分较治疗前均下降(P<0.05),且观察组下降幅度大于对照组(P<0.05);观察组治疗总有效率为96.67%(58/100),高于对照组83.33%(50/60),比较差异有统计学意义(P<0.05)。结论对脾胃虚弱型慢性萎缩性胃炎患者采取针灸联合加味香砂六君汤治疗能有助于进一步改善临床症状,促进腺体萎缩、异型增生等异常胃黏膜组织学的改善,提高治疗疗效。
Objective To investigate the influence of acupuncture combined with Modified Xiangsha Liujunzi Decoction(加味香砂六君子汤)on TCM syndromes,histology and curative effect in the treatment for chronic atrophic gastritis of spleen-stomach deficiency syndrome.Methods A total of 120 cases with chronic atrophic gastritis of spleen-stomach deficiency syndrome were randomly divided into control group and observation group,60 cases in the each group.The two groups were treated with western medicine.Besides,the control group was treated with Modified Xiangsha Liujunzi Decoction and the observation group was treated with acupuncture combined with Modified Xiangsha Liujunzi Decoction.The changes of TCM syndrome scores and histological changes under gastroscopy before and after treatment were observed and the therapeutic effect was evaluated.Results Before treatment,there was no significant difference between the two groups in the scores of symptoms such as stomach preferring warm and pressing,fullness or dull pain of epigastric cavity,loose stool,fatigue,shortness of breath,lazy speech and lack of appetite(P>0.05).The scores after treatment were lower than those before treatment(P<0.05).The decrease degree of the observation group was greater than that of the control group(P<0.05).Gland atrophy,intestinal metaplasia,chronic inflammation,dysplasia and severity of lesion activity were scored under gastroscopy and there was no significant difference in the above scores between the two groups before treatment(P>0.05).The histologic scores were decreased after treatment compared with those before treatment and the decrease amplitude of the observation group was larger than that of the control group and the difference was statistically significant(P<0.05).The total effective rate of treatment was 83.33%(50/60)in the control group and 96.67%(58/60)in the observation group and the difference was statistically significant(P<0.05).Conclusion The acupuncture combined with Modified Xiangsha Liujunzi Decoction in the treatment of
作者
吴灿
邓行行
罗燕文
黎钟山
陈朝露
WU Can;DENG Xingxing;LUO Yanwen;LI Zhongshan;CHEN Chaolu(Qionghai Hospital of Traditional Chinese Medicine,Qionghai 571400,Hainan,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第7期185-188,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局中医药行业科研项目(2019083397)
琼海市科技计划(2020-20)。
关键词
针灸
加味香砂六君子汤
脾胃虚弱证
慢性萎缩性胃炎
中医证候
组织学
疗效
acupuncture
Modified Xiangsha Liujunzi Decoction(加味香砂六君子汤)
spleen-stomach deficiency syndrome
chronic atrophic gastritis
TCM symptoms
histology
curative effect
