摘要
目的探讨南京鼓楼医院宫颈上皮内瘤变Ⅰ级(CINⅠ)人乳头瘤病毒(HPV)感染的分型情况及其转归。方法回顾性研究2010年至2012年在南京鼓楼医院确诊的CINⅠ患者,采用凯普核酸分子快速导流杂交基因芯片技术对HPV进行分型。定期随诊(每半年1次,持续2年),随诊项目包括宫颈液基细胞学检测(TCT)、第二代基因杂交捕获(HC-II)检测HPV(人乳头瘤病毒)。结果 1CINⅠ患者以HPV单一高危型感染为主,150例CINⅠ患者,HPV阳性的患者134例(89.33%),HPV检测阴性16例(10.67%)。单一高危型别感染86例(57.33%),多重感染46例(30.67%),单一低危型别感染2例(1.33%)。2CINⅠ中HPV阳性的患者134例,其中单一感染者88例(65.67%),双重感染30例(22.39%),三重感染10例(7.46%),四重感染6例(4.48%);3HPV52、58、16感染率最高,分别占HPV阳性患者中的27.61%、17.16%、15.67%。4随访过程中,150例CINⅠ患者1年转阴率达62.00%,2年转阴率达80.00%,病程持续2年及病理升级的占20.00%,其中病理升级者占所有患者的12.67%。结论HPV以单一高危型感染为主,其中以HPV52、58、16亚型感染率最高。但在病变持续及进展病例中,以HPV16及18亚型感染率最高。HPV多重感染可能会导致病毒清除时间的延长,是否增加病理升级的风险,需待大样本进一步调查研究。
Objective To investigate the cervical intraepithelial neoplasia grade I( CINⅠ) points in human papilloma virus( HPV)infection situation and its outcome in this hospital. Methods A retrospective study was performed in patients with CINⅠ form 2010 to 2012 in this hospital,HPV was classified with cape nucleic acids rapid diversion hybridization of HPV gene chip technology. The regular follow-up was once every half a year,in two years. Follow-up projects included TCT,HPV HC-II. Results 1Patients with CINⅠ were mainly with single high-risk HPV type infections; of 150 patients with CINI,HPV positive was in 134 cases( 134 /150,89. 33%) and negative in 16 cases( 16 /150,10. 67%). There were 86 cases of single high-risk pattern infection,( 86 /150,57. 33%),46 cases of multiple infections( 46 /150,30. 67%),and 2 cases of single low-risk type infection( 2 /150,1. 33%). 2CINⅠ HPV positive was in 134 cases,in which a single infection was in 88 cases( 88 /134,65. 67%),dual infection in 30 cases( 30 /134,22. 39%),triple infection was in 10 cases( 10 /134,7. 46%),and quadruple infection was in 6 cases( 6 /134,4. 48%). 3 In turn,HPV52,58,16 infection rate was the highest,which was respectively 27.61%,17. 16%,15. 67% of HPV positive patients. 4In the process of follow-up,1 year negative conversion rate of 150 patients with CINⅠ was 62. 00%; two years conversion rate was 80. 00%. Course for two years and pathological upgrade accounted for 20. 00%,and the pathological upgrade accounted for 12. 67% of all patients. Conclusion A single high-risk HPV infection is the main type,with the highest infection rate of HPV52,58,16 subtypes. But in cases of disease duration and progression,HPV16 and 18 subtypes has highest infection rate. Multiple HPV infections can lead to viral clearance extension of time. Large sample for further investigation is still in need with regard to whether to increase the risk of pathological upgrade.
出处
《安徽医学》
2015年第1期23-25,26,共4页
Anhui Medical Journal
基金
江苏省科技厅科技支撑计划-社会发展课题(BE2012606)
关键词
人乳头瘤病毒分型
宫颈上皮内瘤变Ⅰ级
随诊
Human papilloma virus classification
Cervical intraepithelial neoplasia grade I
Follow-up
