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高级别脑胶质瘤术后同步放化疗疗效和生存情况分析 被引量:5

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摘要 目的分析同步放化疗与单纯放疗治疗高级别脑胶质瘤术后患者的疗效。方法 64例高级别脑胶质瘤术后患者被随机分为单纯放疗组(32例)和同步放化疗组(32例),放疗靶区剂量:MRI所示肿瘤病灶外2~3 cm区域给予放疗剂量50 Gy,后缩野至肿瘤病灶外1~2 cm区域加量至60 Gy,2 Gy/次,5次/周。放化疗组放疗期间口服替莫唑胺胶囊75 mg/(m2·d),放疗结束后间隔4周,口服替莫唑胺胶囊200 mg/(m2·d)第1~5 d序贯化疗4个周期。结果同步放化疗组、放疗组1年、2年、3年生存率分别为78.47%、45.43%、16.72%和54.32%、18.21%、8.07%,差异有统计学意义(P<0.05)。两组在血液学毒性上差异有统计学意义(P<0.05),在急性脑损伤与慢性脑损伤方面差异无统计学意义(P>0.05)。结论术后同步放化疗组与单纯放疗组相比,可提高高级别脑胶质瘤术后患者生存率。
出处 《安徽医学》 2014年第6期833-835,共3页 Anhui Medical Journal
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  • 1杨冬,王忠诚,邱晓光,江涛,张亚卓.放、化疗同步治疗高级别胶质瘤[J].中华神经外科疾病研究杂志,2007,6(5):450-453. 被引量:20
  • 2谷铣之,殷蔚伯,余子豪,等.肿瘤放射治疗学[M].4版北京:中国协和医科大学出版社,2007:1122-1125. 被引量:1
  • 3Stupp R, Masn WP, van den Bent MJ, et al. Radiontherapy plus concomitant and adjuvant temozolomide for glioblastoma[J]. NEngIJ Med, 2005, 352(10): 987 -996. 被引量:1
  • 4Iuchi T, Hatano K, Narita Y, et al. Hypofractionated high- dose irradiation for the treatment of malignant astrocytomas using simultaneous integrated boost technique by IMRT[J]. Int J Radiat Oneol Biol Phys, 2006, 64(5) : 1317-1324. 被引量:1
  • 5CorsaP, Pafisi S, Raguso A, et al. Temozolimide and radiotherapy as first-line treatment of high'grade gliomas[J]. Tumor, 2006, 92(4): 299- 305. 被引量:1
  • 6van Rin J, Heimans JJ, van den Berg J, et al. Survival of human glioma cells treated with various combination of temozolomide and X-rays[J]. Int J Radiat Oncol Biol Phys,2000, 47(3): 779-784. 被引量:1
  • 7Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase study: 5-year analysis of the EORTC- NCIC trial[J]. Lancet Oncol, 2009, 10(5) : 459-466. 被引量:1
  • 8Papuashvili GS, Gagua RO, Ninua NG. Temozolomide-a new antitumor preparation in the treatment of central nervous system malignant tumors [J]. Georgian Med News, 2006(134), 31-34. 被引量:1
  • 9王若峥,王多明.调强放疗与替莫唑胺联合治疗颅内恶性胶质瘤16例临床分析[J].广西医科大学学报,2008,25(5):796-797. 被引量:6
  • 10陈焕雄,曹作为,李钢,陈敏,符俊骐,高宁.脑胶质瘤选择性颈动脉化疗42例临床分析[J].海南医学院学报,2010,16(2):202-204. 被引量:5

共引文献11

同被引文献78

  • 1杨学宁,吴一龙.实体瘤治疗疗效评价标准——RECIST[J].循证医学,2004,4(2):85-90. 被引量:1568
  • 2张华楸,舒凯,叶飞,郭东升,牛洪泉,雷霆,李龄.脑胶质瘤病的诊断和治疗[J].中华神经医学杂志,2005,4(6):582-584. 被引量:10
  • 3周绍兵,刘阳晨,高飞,叶宏勋,赵莺,尹小祥.恶性脑胶质瘤术后替莫唑胺化疗联合适形放疗的疗效观察[J].现代肿瘤医学,2008,16(1):34-35. 被引量:9
  • 4Stupp R, Mason WP, Vanderbent M, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblatoma[J]. N Engl J Med, 2005, 352(10): 987-996. 被引量:1
  • 5Theeler BJ, Groves MD. High-grade gliomas[J]. Curt Treat Options Neurol, 2011,13(4) : 386-399. 被引量:1
  • 6van rijn J, Heimans JJ, van den Berg J, et al. survival of hu- man glioma cells treated with various combination of temozolo- mide and X-ray[J]. Int J Radiat Oncol Biol Phys, 2000, 47 (3) : 779-784. 被引量:1
  • 7Mineo JF, Bordron A, Baroncini M, et al. Prognosis factors of survival time in patients with glioblastoma multiforme : a multi- variate analysis of 340 patientsFJ]. Acta Neuroehir (Wien), 2007, 149(3): 245 -252. 被引量:1
  • 8Balducci M, D'Agostino GR, Manfrida S, et al. Radiotherapy and concomitant temozolomide during the first and last weeks in high grade gliomas: long-term analysis of a phase Ⅱ study [J]. J Neuroncol, 2010, 97(1).- 95-100. 被引量:1
  • 9Valeriani M, Ferretti A, Franzese P, et al. High-grade glio- mas: results in patients treated with adjuvant radiotherapy a- lone and with adjuvant radio-chemotherapy[J]. Anticaneer Res,2006, 26(3B):2 429-2 435. 被引量:1
  • 10Song-Τao Qi,Lei Yu,Yun-Tao Lu,Yang-Hui Ou,Zhi-Yong Li,Lan-Xiao Wu,Fei Yao.??IDH mutations occur frequently in Chinese glioma patients and predictlonger survival but not response to concomitant chemoradiotherapy in anaplasticgliomas(J)Oncology Reports . 2011 (6) 被引量:1

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