摘要
过氧化物酶体增殖是细胞对多种化合物如某些天然的或修饰过的脂肪酸、邻苯二甲酸盐、白三烯拮抗物、乙酰唾液酸等或者某种病理状态如细胞形态、酶活性剧变等反应的结果。过氧化物酶体增殖现象主要发生在肝、肾、脂肪等组织,激素和营养因子都能调节过氧化物酶体增殖反应。持续的过氧化物酶体增殖可导致肝癌。组织特异性表达的三种过氧化物酶体增殖体激活受体(peroxisomeproliferatoractivatedreceptor,PPAR)包括PPARα、PPARβ、PPARγ,三者组成独特的细胞核受体亚族。经过十几年的科学研究,PPAR的功能已比较明晰。研究表明,PPARγ基因作为节俭基因的主控基因,调控着与脂肪生成、糖尿病、肥胖相关基因的表达,该受体还参与多种细胞生理活动的转录调控,包括细胞周期调控、炎症、免疫调节、肿瘤细胞的活动。
Chang Yong-sheng Fang Fu-de (National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing100005,China)abstrcat Peroxisome proliferation is a cellular response to many chemical compounds affects including natural and modified fatty acids,phthalate and adipate ester plasticizers,leukotriene antagonists,acetylsalicylic acid and certain pathophysiological conditions including dramatic change of cellular morphology and enzymatic activity.Peroxisome proliferation phenomenon is seen primarily in liver and kidney.Hormones and nutritional factor can regulate peroxisome proliferation response.Sustained peroxisome proliferation can lead to hepatocarcinogenesis.The three types of peroxisome proliferator activated receptor,termed PPARα,PPARβ,and PPARγ,expressed in specific tissue,are consisted of a specific nuclear receptor superfamily.After more than10years world wide research,the function of PPAR is clarified,as PPARγ,the master of thrifty genes,controls the expression of genes relative to adipogenesis,diabetes mellitus and obesity.The receptor is involved in transcriptional control of numerous cellular processes including cell cycle control,inflammation,immunoregulation and carcinogenesis.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2002年第3期315-320,共6页
Acta Academiae Medicinae Sinicae
